[关键词]
[摘要]
【目的】 探讨黄健玲教授治疗盆腔炎性疾病(PID)的用药特点与组方规律。【方法】 收集2021年10月至2024 年9月期间 就诊于广东省中医院黄健玲教授门诊,诊断为 PID且经中药内服治疗有效的患者的初诊病历资料,基于中医传承辅助平台 (V2.5 版)系统,对患者的症状频次、证型频次、药物频次、四气五味分布、归经分布与功效分类进行统计,运用关联规则 分析及聚类分析的方法,挖掘其用药规律与经验。【结果】 共纳入217则医案,患者症状共计63个,出现频次居前5位的主症 为下腹痛、痛经、失眠、带下量多、不孕。证型19个,以脾虚湿蕴证、湿热瘀阻证、肾虚血瘀证多见。243首中药处方共涉 及药物78味,药物累计使用2 856次。使用频次 ≥ 50次的高频药物共20味,频次居前的中药为毛冬青、丹参、赤芍、白术、 茯苓、当归、桑寄生、败酱草、郁金、香附、路路通等。所用药物以平性药为主,寒性药与温性药次之;五味以苦味为主, 甘味与辛味药物次之;药物的归经以归肝、脾、肾三经为主。药物的功效共分15类,以补虚药、活血化瘀药为主。关联规 则分析结果显示,毛冬青、丹参、赤芍、白术、茯苓、当归、桑寄生为治疗PID的核心药物;针对PID的主症下腹痛,通常 加用香附、败酱草;针对主症痛经,通常加用香附、木香、路路通、败酱草;针对主症失眠,通常加用郁金;针对主症带下量多,通常加用香附、木香、败酱草、郁金、粉萆薢;针对主症不孕,通常加用路路通、穿破石、菟丝子。聚类分析得 到新方组合4个。【结论】 黄健玲教授辨治PID以虚实夹杂为其病机特点,以湿、热、瘀邪实为主,兼有脾肾气虚,治疗当化 瘀通络、清热利湿,兼顾健脾补肾。
[Key word]
[Abstract]
Objective To explore the medication characteristics and prescription patterns of Professor Huang Jianling in treating pelvic inflammatory disease (PID). Methods Medical records of first-visit patients diagnosed with PID at Professor Huang Jianling’s outpatient clinic in Guangdong Provincial Hospital of Chinese Medicine between October 2021 and September 2024,who showed effective response to oral Chinese medicine treatment, were collected. Based on the Traditional Chinese Medicine Inheritance Support System (V2.5), statistics were performed on the occurrence frequency of symptoms,syndrome types and herbs,as well as the distribution of four natures,five flavors,meridian tropism,and efficacy categories of the herbs. Association rule analysis and cluster analysis were employed to excavate her medication patterns and clinical experience. Results A total of 217 medical records was included,involving 63 symptoms. The top 5 frequently-seen main symptoms were lower abdominal pain, dysmenorrhea, insomnia, profuse leukorrhea, and infertility. Nineteen syndrome type were identified, and the most common type were spleen deficiency with dampness accumulation syndrome,damp-heat and blood stasis obstruction syndrome, and kidney deficiency with blood stasis syndrome. The 243 Chinese medicine prescriptions involved 78 herbs,with a cumulative occurrence frequency of 2 856 times. Twenty high-frequency herbs were used 50 times or more. The most frequently-used herbs were Ilex Pubescens Radix, Salviae Miltiorrhizae Radix et Rhizoma,Paeoniae Radix Rubra,Atractylodis Macrocephalae Rhizoma,Poria,Angelicae Sinensis Radix, Taxilli Herba, Patriniae Herba, Curcumae Radix, Cyperi Rhizoma, and Liquidambaris Fructus. The herbs used were mainly neutral in nature,followed by cold and warm properties. The primary flavor was bitter,followed by sweet and pungent flavors. Most of the herbs had the meridian tropism of the liver,spleen, and kidney meridians. The herbal efficacies were classified into 15 categories, and tonifying herbs and bloodactivating and stasis-resolving herbs ranked ahead of other herbs. Association rule analysis revealed that Ilex Pubescens Radix,Salviae Miltiorrhizae Radix et Rhizoma,Paeoniae Radix Rubra,Atractylodis Macrocephalae Rhizoma, Poria, Angelicae Sinensis Radix, and Taxilli Herba constituted the core herbal combination for treating PID. For the main symptom of lower abdominal pain,Cyperi Rhizoma and Patriniae Herba were typically added; for dysmenorrhea, Cyperi Rhizoma, Aucklandiae Radix, Liquidambaris Fructus and Patriniae Herba were usually added;for insomnia,Curcumae Radix was usually added;for profuse leukorrhea,Cyperi Rhizoma, Aucklandiae Radix,Patriniae Herba,Curcumae Radix and Dioscoreae Hypoglaucae Rhizoma were often added; for infertility, Liquidambaris Fructus, Cudraniae Radix and Cuscutae Semen were frequently added. Cluster analysis yielded 4 potential new formula combinations. Conclusion For the syndrome differentiation and treatment of PID, Professor Huang Jianling holds a view that PID has a complex pathogenesis of deficiency and excess, characterized by the pathogenic excess of dampness, heat and stasis, and accompanied by spleen-kidney qi deficiency. The treatment of PID should be focused on resolving stasis and unblocking collaterals,clearing heat and draining dampness,while concurrently fortifying the spleen and tonifying the kidney.
[中图分类号]
R271.9
[基金项目]
广东省中医药局中医药科研项目(编号:20254072);全国名老中医药专家黄健玲名医传承工作室建设项目(国中医药人教函 〔2022〕75号);广州市科技计划项目(编号:2023A04J0463)