【目的】 观察疏肝调神电针法联合西药治疗女性更年期抑郁症的临床疗效。【方法】 选取 2024年 1月至 2025年 1月广东 医科大学顺德妇女儿童医院中医科收治的90例明确诊断为女性更年期抑郁症的患者为研究对象。按照随机数字表法将患者 随机分为观察组与对照组，每组各45例。对照组给予常规西药治疗，观察组在对照组治疗的基础上，给予疏肝调神电针法 治疗。共治疗3个月。治疗3个月后，评价2组临床疗效。观察2组患者治疗前后汉密尔顿抑郁量表（HAMD）17项评分、汉密 尔顿焦虑量表（HAMA）评分和Kupperman指数的变化情况，以及雌二醇（E2 ）、垂体促卵泡刺激素（FSH）、促黄体生成素（LH） 与孕酮（P）水平的情况。比较 2组患者治疗前后去甲肾上腺素（NE）、5-羟色胺（5-HT）、多巴胺（DA）水平的变化情况。并评 价 2组的安全性及不良反应的发生情况。【结果】（1）治疗后，2组患者的 HAMD、HAMA、Kupperman指数评分均明显改善， 且观察组在改善HAMD、HAMA、Kupperman指数评分方面明显优于对照组，差异有统计学意义（P＜0.05）。（2）治疗后，2组 患者E2、FSH、LH与P水平明显改善（P＜0.05），且观察组在改善E2、FSH、LH与P水平方面明显优于对照组，差异有统计 学意义（P＜0.05）。（3）治疗后，2组患者NE、5-HT、DA水平明显改善（P＜0.05），且观察组在改善NE、5-HT、DA水平方面 明显优于对照组，差异有统计学意义（P＜0.05）。（4）观察组总有效率为95.56%（43/45），对照组为77.78%（35/45）。观察组疗 效优于对照组，差异有统计学意义（P＜0.05）。（5）治疗期间，观察组不良反应发生率为4.44%（2/45）；对照组为17.78%（8/45）； 观察组的不良反应发生率低于对照组，差异有统计学意义（P＜0.05）。【结论】 疏肝调神电针法联合西药治疗女性更年期抑郁 症，可有效改善患者焦虑和抑郁的情绪状态，缓解患者的临床症状，对患者内分泌状态与神经递质水平具有明显的调节作 用，且安全性好，临床疗效显著。

Objective To observe the clinical efficacy of Liver-Soothing and Mind-Regulating Electroacupuncture combined with western medicine in treating menopausal depression in women. Methods Ninety patients diagnosed with menopausal depression at the Department of Traditional Chinese Medicine，Shunde Women and Children’s Hospital of Guangdong Medical University from January 2024 to January 2025 were selected as the study subjects. The patients were randomly divided into an observation group and a control group using a random number table， with 45 cases in each group. The control group received conventional western medicine treatment， while the observation group received Liver-Soothing and Mind-Regulating Electroacupuncture in addition to the treatment given to the control group. The treatment duration was 3 months. After 3 months of treatment，the clinical efficacy of the two groups was evaluated. Changes in the 17-item Hamilton Depression Rating Scale （HAMD） score， Hamilton Anxiety Rating Scale （HAMA） score， and Kupperman Index， as well as levels of estradiol （E2 ）， follicle-stimulating hormone （FSH），luteinizing hormone （LH），and progesterone （P），were observed before and after treatment in both groups. Changes in levels of norepinephrine （NE），serotonin （5-HT），and dopamine （DA） were compared before and after treatment. Safety and incidence of adverse reactions were also assessed in both groups. Results （1）After treatment， HAMD， HAMA， and Kupperman Index scores were significantly improved in both groups，and the observation group showed significantly greater improvement in these scores than the control group，with a statistically significant difference （P＜0.05）.（2） After treatment，levels of E2，FSH， LH，and P significantly were improved in both groups （P＜0.05），and the observation group showed significantly greater improvement in these hormone levels than the control group，with a statistically significant difference （P＜ 0.05）.（3） After treatment，levels of NE，5-HT，and DA were significantly improved in both groups （P＜0.05）， and the observation group showed significantly greater improvement in these neurotransmitter levels than the control group，with a statistically significant difference （P＜0.05）.（4） The total effective rate was 95.56% （43/45） in the observation group and 77.78%（35/45） in the control group. The efficacy of the observation group was superior to that of the control group，with a statistically significant difference（P＜0.05）.（5） During treatment，the incidence of adverse reactions was 4.44%（2/45） in the observation group and 17.78% （8/45） in the control group. There was no statistically significant difference in the incidence of adverse reactions between the two groups （P＞0.05）. Conclusion Liver-Soothing and Mind-Regulating Electroacupuncture combined with western medicine effectively improves anxiety and depressive symptoms， alleviates clinical manifestations， and significantly regulates endocrine status and neurotransmitter levels in patients with menopausal depression，with good safety and notable clinical efficacy.

R246.9

广东省自然科学基金资助项目（编号：2021A1515011464）