【目的】 基于西北燥证主证与肺结核的病证相关性，探讨以干旱地区气候环境为背景的西北燥证对肺结核患者的影响， 为采取优化环境等辅助治疗改善肺结核患者生活质量寻找科学依据。【方法】 采用西北燥证主证诊断量表调研 2023年 1月至 2024年12月期间在新疆阿克苏市传染病医院就诊且在新疆居住时长 ≥ 3年的肺结核患者（病例组）与同期在阿克苏地区多个 社区人群中未患肺结核及其他相关疾病且在新疆居住时长 ≥ 3年的健康人群（健康对照组）西北燥证的罹患率，比较2组的西 北燥证证候积分；采用肺结核临床症状评分表评估肺结核患者的西医病情，根据是否罹患西北燥证，将肺结核病例分为携 证型肺结核组与非携证型肺结核组，比较2组患者的病情轻重；采用中医辨证方法辨识肺结核患者的中医证型，比较携证型 肺结核组与非携证型肺结核组患者的中医证型分布差异。【结果】（1）肺结核病例组的西北燥证罹患率为47.00%（94/200），明 显高于健康对照组的31.00%（62/200），组间比较（卡方检验），差异有统计学意义（P＜0.01）。（2）肺结核病例组的西北燥证积 分明显高于健康对照组，差异有统计学意义（P＜0.01）。（3）携证型肺结核组的西医病情积分明显高于非携证型肺结核组，差 异有统计学意义（P＜0.01）。（4）携证型肺结核与非携证型肺结核的中医证型分布由高到低均依次为肺阴虚证、气阴两虚证、 阴阳两虚证。携证型肺结核组与非携证型肺结核组的中医证型分布比较，差异有统计学意义（P＜0.01），其中，携证型肺结 核组的肺阴虚证患者占比低于非携证型肺结核组，携证型肺结核组的气阴两虚证、阴阳两虚证患者占比均高于非携证型肺 结核组。【结论】 西北燥证与新疆地区肺结核的发病存在紧密联系，是该地区人群罹患肺结核的关键因素之一。

Objective Based on the correlation between the main syndrome of northwest dryness syndrome （NDS） and pulmonary tuberculosis （TB），this study preliminarily explores the impact of NDS，having the features of the arid regional climate and environment， on TB patients in Xinjiang. It aims to provide a scientific basis for employing auxiliary treatments，such as environmental optimization，to improve the quality of life for TB patients. Methods Using the main syndrome diagnostic scale for NDS， the prevalence of NDS was investigated in two groups：a case group consisting of TB patients （with a residence duration in Xinjiang ≥ 3 years） attending the Aksu Infectious Disease Hospital，between January 2023 and December 2024，and a healthy control group （without TB or other related diseases，with a residence duration in Xinjiang ≥ 3 years） selected from multiple communities in the Aksu region during the same period. The NDS syndrome scores were compared between the two groups. The clinical symptom scoring scale for TB was used to assess the western medical disease severity in TB patients. Based on the presence or absence of NDS，TB cases were divided into a TB-with-NDS group and a TB-without-NDS group， and their disease severity was compared. Traditional Chinese medicine （TCM） syndrome types were identified in TB patients using TCM syndrome differentiation methods， and the distribution differences of TCM syndrome types were compared between the TB-with-NDS and TB-without-NDS groups. Results （1）The prevalence of NDS in the TB case group was 47.00% （94/200），significantly higher than the 31.00% （62/200） in the healthy control group. The intergroup comparison （by chi-square test） showed a statistically significant difference（P＜0.01）.（2） The NDS syndrome score in the TB case group was significantly higher than that in the healthy control group， with a statistically significant difference （P＜0.01）.（3） The western medical disease severity score in the TB-with-NDS group was significantly higher than that in the TB-without-NDS group，with a statistically significant difference （P＜0.01）.（4） The distribution of TCM syndrome types in both the TB-withNDS group and TB-without-NDS group in descending order was lung yin deficiency syndrome， qi and yin deficiency syndrome， and yin and yang deficiency syndrome. The comparison of TCM syndrome distribution between the TB-with-NDS group and TB-without-NDS group showed a statistically significant difference （P＜ 0.01）. Specifically，the proportion of patients with lung yin deficiency syndrome was lower in the TB-with-NDS group than in the TB-without-NDS group，while the proportions of patients with qi and yin deficiency syndrome and yin and yang deficiency syndrome were higher in the TB-with-NDS group than the TB-without-NDS group. Conclusion NDS is closely associated with the incidence of TB in the Xinjiang region，and is one of the key factors contributing to TB susceptibility in this population.

R259.21

省部共建中亚高发病成因与防治国家重点实验室开放课题（编号：SKL-HIDCA-2022-XBZZ15）