干燥综合征是一种常见的慢性进展性自身免疫性疾病，其病情易缠绵反复，且常伴有神经系统、肌肉骨骼、肺、血 液等多系统损伤，严重影响患者生活质量。该文基于“脾气散精”理论，认为干燥综合征的发病、进展和治疗均与脾密切 相关，其中脾失健运、精微不布是其发病核心机理，并以“助脾散精”为总的治疗原则，提出运用“运脾化湿，调畅气机” “培土生金，开宣达郁”“健脾益气，化气生津”“活血祛瘀，畅通脾络”等治法，以缓解干燥综合征的症状及防治其并发 症，促进疾病向愈。“助脾散精”论治干燥综合征及其并发症，拓展了中医临床治疗干燥综合征的思路。

Sjögren’s syndrome is a common chronic progressive autoimmune disease characterized by a protracted and relapsing course， often accompanied by multi-system damages involving the nervous， musculoskeletal， pulmonary，and hematological systems，which significantly impair patients’ quality of life. Based on the theory of spleen qi in charge of dispersing essence，this article posits that the onset，progression，and treatment of Sjögren’s syndrome are closely related to spleen dysfunction，and the core pathogenesis of Sjögren’s syndrome is due to the failure of spleen in transportation，which results into the failure in dispersing essence. Following the overarching therapeutic principle of assisting the spleen in dispersing essence，the specific treatment strategies were proposed， i. e.，activating spleen to resolve dampness and regulating qi movement，reinforcing earth （spleen） to generate metal （lung） and promoting diffusion to relieve stagnation，fortifying spleen and boosting qi to transform qi and generate fluids，and activating blood to remove stasis and unblocking the spleen collaterals. These approaches aim to alleviate symptoms of Sjögren’s syndrome，prevent and manage its complications，and promote its recovery. The treatment of Sjögren’s syndrome and its complications based on the theory of assisting the spleen in dispersing essence expands the clinical therapeutic method of traditional Chinese medicine for this condition.

R259.932

第四届国医大师传承工作室建设项目（国中医药办人教函 〔2022〕 245 号 1123-04）；国家中医药传承创新中心建设项目（编号： 202203）；山西省中医临床医学研究中心（培育）项目（晋科社发 〔2019〕 61 号）；山西省卫健委山西省医学科技创新团队项目（编号： 2020TD04）；山西省卫健委山西省医学重大科技攻关专项（编号：2022XM10）