动脉粥样硬化性心血管疾病（ASCVD）是以动脉粥样硬化为病理基础，以免疫炎症反应为主要病理改变的一类慢性疾 病。体质因素决定了ASCVD的病机与证候的演变和发展，与ASCVD相关的偏颇体质类型中，虚性偏颇体质包括气虚质、阳 虚质和阴虚质，实性偏颇体质包括痰湿质和血瘀质。调体防病可运用于ASCVD的防治。针对ASCVD的高危体质类型，以中 医体质理论为指导，采用扶正祛邪原则调节机体免疫炎症反应，可早期预防和干预ASCVD，方法如下：未病先防，扶正为 先；欲病救萌，祛邪抗炎；已病早治，扶正与祛邪并重。基于扶正祛邪的原则调节偏颇体质状态，以切断ASCVD的免疫炎 症反应这一关键病理途径，有助于预防ASCVD的发生和早期干预该病之进程，体现了中医治未病的重要思想，可为ASCVD 的防治提供新的思路与方法。

Atherosclerotic cardiovascular disease （ASCVD） is a chronic condition developed from atherosclerosis and characterized by immune-inflammatory responses as the primary pathological manifestation. Constitutional factors determine the evolution and progression of the pathogenesis and syndrome presentations of ASCVD. The biased constitution types associated with ASCVD consisted of the deficient constitutions of qi deficiency， yang deficiency， and yin deficiency， and the excess constitutions of phlegm-damp and blood stasis. Constitutionregulating and disease-prevention approach can be applied in the management of ASCVD. For ASCVD patients with high-risk constitution types，the principle of strengthening healthy qi and eliminating pathogens based on the theory of traditional Chinese medicine （TCM） constitution is adopted to modulate the body’s immune-inflammatory response，thereby enabling early prevention and intervention of ASCVD. The approaches are as follows：for the preventive treatment before disease onset，strengthening healthy qi is prioritized；for the intervention of the early signs of disease， methods of eliminating pathogens and counteracting inflammation are adopted； for the early treatment of disease， strengthening healthy qi and eliminating pathogens simultaneously are emphasized. The regulation of biased constitution states based on the principle of strengthening healthy qi and eliminating pathogens helps to disrupt the key pathological pathway of immune-inflammatory responses in ASCVD. This approach contributes to preventing the onset of ASCVD and the early intervention of its progression， embodying the important TCM concept of preventive treatment of disease and potentially offering novel strategies and methods for the prevention and management of ASCVD.

R259.435

国家自然科学基金项目（编号：82374389，82305140）；广东省自然科学基金项目（编号：2023A1515011103）；广州市科技局 科研项目（编号：2024A04J4329）；广东省中医药局科研项目（编号：20241097）