【目的】 采用数据挖掘方法分析钟广玲教授治疗湿热痹阻证膝痹的组方用药规律。【方法】 收集 2020年 1月至 2024年 12月期间钟广玲教授于佛山市中医院治疗湿热痹阻证膝痹且有效的病例的门诊处方，建立病案数据库，采用Excel 2021对数 据库中的药物使用频次、性味归经分布进行分析；运用 SPSS Modeler 18.0、Cytoscape 3.9.1 软件对药物进行关联规则分析及 聚类分析。【结果】 共纳入处方184首，使用中药达到212味。出现频次居前10位的药物依次为薏苡仁、黄柏、苍术、牛膝、 木瓜、威灵仙、忍冬藤、白芍、虎杖、葛根。所用药物的药味多辛、苦、甘，药性以平、温为主，主要归肝、脾、肾经。 关联规则分析得到的核心药物为牛膝、薏苡仁、黄柏、苍术、木瓜、忍冬藤、威灵仙、虎杖、白芍。对药物出现频次居前 30位的高频中药进行聚类分析，结果共聚为10类。【结论】 钟广玲教授采用中药治疗湿热痹阻证膝痹以清热利湿、祛风通络 法为主，从肝、脾、肾经入手，辅以补肝肾强筋骨、调和脾胃之法；同时注重补气养血，顾护胃气；用药通常以四妙散加 减，且擅长运用藤类药物。

Objective To explore the medication patterns in Professor Zhong Guangling’s prescriptions for knee arthralgia with damp-heat obstruction syndrome using data mining methods. Methods From January 2020 to December 2024， the prescriptions for effective outpatient cases of knee arthralgia with damp-heat obstruction syndrome treated by Professor Zhong Guangling at Foshan Hospital of Traditional Chinese Medicine were collected. A medical record database was established. Excel 2021 was used to analyze the occurrence frequency of herbs and the distribution of herbal properties，flavors，and meridian tropisms. SPSS Modeler 18.0 and Cytoscape 3.9.1 were employed for association rule analysis and cluster analysis of the Chinese herbal medicines. Results A total of 184 prescriptions were included，involving 212 distinct herbal medicines. The top 10 herbs by frequency of use were Coicis Semen， Phellodendri Chinensis Cortex， Atractylodis Rhizoma， Achyranthis Bidentatae Radix， Chaenomelis Fructus， Clematidis Radix et Rhizoma， Lonice Raejaponicae Caulis， Paeoniae Radix Alba， Polygoni Cuspidati Rhizoma，and Puerariae Lobatae Radix. The medicinals were predominantly pungent，bitter， and sweet in flavor，and were neutral or warm in nature，mainly attributing to the liver，spleen，and kidney meridians. Association rule analysis identified the core herbs of Achyranthis Bidentatae Radix， Coicis Semen， Phellodendri Chinensis Cortex， Atractylodis Rhizoma， Chaenomelis Fructus， Lonice Raejaponicae Caulis， Clematidis Radix et Rhizoma，Polygoni Cuspidati Rhizoma，and Paeoniae Radix Alba. Cluster analysis of the top 30 high-frequency herbs resulted in 10 distinct clusters. Conclusion For the treatment of knee arthralgia with damp-heat obstruction syndrome with Chinese herbal medicine，Professor Zhong Guangling primarily employs the therapies of clearing heat and draining dampness，dispelling wind and unblocking collaterals，targeting the liver， spleen，and kidney meridians. This approach is supplemented by the methods of tonifying the liver and kidney， strengthening tendons and bones， and harmonizing the spleen and stomach. Simultaneous attention is given to supplementing qi and nourishing blood，and protecting stomach qi. Simiao San is usually adopted by modifications for the medication，and Professor Zhong demonstrates expertise in the application of vine medicinals.

R274.9

徐志强广东省名老中医药专家传承工作室建设项目（粤中医办函[2020]1号）