[关键词]
[摘要]
慢性疲劳综合征(CFS)是一种以持续疲劳为核心症状的复杂疾病,中医“脾主运化”理论为其治疗提供了独特视角。 该研究构建“脾主运化-菌群稳态-线粒体能量代谢”理论模型,提出针灸通过调控“肠道菌群-线粒体”轴改善 CFS 的机 制,并解析针灸治疗的优势及疗效差异。结果表明,针灸可以恢复肠道菌群稳态,抑制线粒体氧化应激反应,增强线粒体 ATP合成能力,可为针灸治疗CFS提供新的理论依据。
[Key word]
[Abstract]
Chronic fatigue syndrome (CFS) is a complex disease characterized by persistent fatigue as the core symptom. The traditional Chinese medicine theory of “Spleen Governing Transportation and Transformation” provides a unique perspective for its treatment. This study establishes a theoretical model of “Spleen Governing Transportation and Transformation-Microbiota Homeostasis-Mitochondrial Energy Metabolism”, proposing that acupuncture improves CFS through regulation of the “gut microbiota-mitochondria” axis, and analyzes the advantages and efficacy differences of acupuncture treatment. Results demonstrate that acupuncture can restore gut microbiota homeostasis, inhibit mitochondrial oxidative stress, and enhance mitochondrial ATP synthesis capacity,providing a new theoretical basis for acupuncture treatment of CFS.
[中图分类号]
R246.9
[基金项目]
广东省基础与应用基础研究基金自然科学基金面上项目(编号:2023A1515011411);广东省科技厅农村科技(特派员)项目 (编号:KTPYJ2021026);深圳市南山区高层次医学团队引进项目(编号:SZSM202103010);广州中医药大学“双一流”与高水平大学学 科高质量发展“筑峰造尖”行动计划“固本工程”项目(编号:GZY2025GB0204)