【目的】 观察调经促孕十三针联合腹部任脉及八髎穴铺姜灸治疗早发性卵巢功能不全（POI）的临床疗效。【方法】 选取 2022年4月至2023年3月东莞市中医院治未病科门诊收治的60例明确诊断为POI的患者为研究对象。按随机数字表将患者随 机分为观察组和对照组，每组30例。对照组给予腹部任脉及八髎穴铺姜灸治疗，观察组在对照组治疗的基础上，给予调经 促孕十三针治疗，共治疗3个月。治疗3个月后，评价2组临床疗效。观察2组患者治疗前后Kupperman评分的变化情况，以 及基础窦卵泡计数（AFC）、排卵期子宫内膜厚度的情况。比较2组患者治疗前后血清卵泡刺激素（FSH）、雌二醇（E2）、抗穆 勒氏管激素（AMH）水平的变化情况。【结果】（1）治疗后，2 组患者的 Kupperman 评分明显改善（P＜0.05），且观察组在改善 Kupperman 评分方面明显优于对照组，差异有统计学意义（P＜0.05）。（2）治疗后，2组患者的 AFC 及子宫内膜厚度明显改善 （P＜0.05），且观察组在改善AFC及子宫内膜厚度方面明显优于对照组，差异有统计学意义（P＜0.05）。（3）治疗后，2组患者 的 FSH、E2、AMH 水平明显改善（P＜0.05），且观察组在改善 FSH、E2、AMH 水平方面明显优于对照组，差异有统计学意 义（P＜0.05）。【结论】 调经促孕十三针联合腹部任脉及八髎穴铺姜灸治疗 POI，能明显改善患者的临床症状，有效调节性激 素水平，改善卵巢功能，疗效显著。

Objective To observe the clinical efficacy of Menstruation-Regulating and Fertility-Promoting Thirteen Needles combined with ginger moxibustion on the conception vessel （CV） and Baliao points in the treatment of premature ovarian insufficiency （POI）. Methods Sixty patients diagnosed with POI in the Outpatient Department of Preventive Treatment at Dongguan Traditional Chinese Medicine Hospital from April 2022 to March 2023 were selected as study subjects. Patients were randomly divided into an observation group and a control group using a random number table method，with 30 patients in each group. The control group received ginger moxibustion on the conception vessel and Baliao points，while the observation group received Menstruation-Regulating and FertilityPromoting Thirteen Needles in addition to the control group’s treatment. The treatment course for both groups was 3 months. After 3 months of treatment，clinical efficacy was evaluated in both groups. Changes in Kupperman scores，antral follicle count （AFC），and endometrial thickness during the ovulation phase were observed. Serum levels of follicle-stimulating hormone （FSH）， estradiol （E2）， and anti-Müllerian hormone （AMH） were compared between the two groups before and after treatment. Results （1） After treatment，Kupperman scores were significantly improved in both groups （P＜0.05），and the improvement in the observation group was significantly superior to that in the control group，with a statistically significant difference （P＜0.05）.（2） After treatment， AFC and endometrial thickness were significantly improved in both groups （P＜0.05），and the improvements in the observation group were significantly superior to those in the control group， with statistically significant differences （P＜0.05）.（3） After treatment，serum levels of FSH，E2，and AMH were significantly improved in both groups （P＜0.05），and the improvements in the observation group were significantly superior to those in the control group，with statistically significant differences （P＜0.05）. Conclusion Menstruation-Regulating and FertilityPromoting Thirteen Needles combined with ginger moxibustion on the conception vessel and Baliao points significantly alleviates clinical symptoms，effectively regulates sex hormone levels，and improves ovarian function in patients with POI，demonstrating notable therapeutic efficacy.

R246.9

广东省中医药局科研资助项目（编号：202204180928559100）；东莞市社会发展科技资助项目（编号：20221800900112）