【目的】 运用数据挖掘技术，探讨梁雪芳教授辨治子宫内膜异位症痛经的用药规律。【方法】 选取2014年1月至2024年 1 月期间梁雪芳教授在广东省中医院门诊诊治有效的子宫内膜异位症痛经患者的资料，使用 R 语言及 SPSS Statistics 26、 SPSS Modeler 18、Microsoft Excel 2021软件，统计分析子宫内膜异位症痛经的证型及其治疗药物的使用频次和药物的性味归 经与功效归类，并通过药物关联规则分析以及因子分析挖掘梁雪芳教授辨治子宫内膜异位症痛经的用药规律。【结果】 共纳入有 效病历7 019份，中药处方7 019首，涉及中药225味，其中出现频率大于5%的高频中药共有37味，最常运用的5味药物为 白术、丹参、桑寄生、党参、茯苓，其次为三棱、郁金、菟丝子、莪术等。证型以气虚血瘀、肾虚血瘀、气滞血瘀居多。 药性以寒、温、平为主，药味以苦、甘、辛居多，归经主要归脾、肝、肾经，功效归类以补虚药和活血化瘀药为主。 药物 之间的关联规则分析得到14个药物组合，支持度居前的药物组合为白术-桑寄生、白术-茯苓、白术-白芍、莪术-三棱、丹 参-三棱等。证型与高频中药的关联规则分析显示，与气虚血瘀证关联的中药主要是圣愈汤加延胡索、益母草、枳壳、郁 金；与肾虚血瘀证关联的中药主要是寿胎丸合二至丸加桑椹、山药、生地黄；与气滞血瘀证关联的中药主要是当归芍药散 加丹参、桑寄生、木香；与脾虚湿瘀证关联的中药主要是参苓白术散加三棱、莪术、黄芪、鸡内金；与寒凝血瘀证关联的 中药主要是少腹逐瘀汤加三棱、莪术、山楂、木香、郁金。因子分析得到8个因子。高频中药主要可聚为6类。【结论】 梁雪 芳教授认为，“虚”“瘀”为子宫内膜异位症痛经的病机特点，治疗以 “补虚化瘀” 为原则，联合运用月经周期疗法（经期 活血化瘀，经后期滋阴养血，经间期活血通络助排卵，经前期疏肝理气），能有效改善子宫内膜异位症患者的痛经症状。

Objective To investigate Professor Liang Xuefang medication patterns in treating endometriosisassociated dysmenorrhea using data mining techniques. Methods Clinical data of outpatients with effective treatment outcomes treated by Professor Liang Xuefang at Guangdong Provincial Hospital of Chinese Medicine between January 2014 and January 2024 were collected. R language，SPSS Statistics 26，SPSS Modeler 18，and Microsoft Excel 2021 were employed to analyze syndrome types， herbal usage frequency， herbal properties （nature，flavor，meridian tropism），and categories of herbal therapeutic actions. Association rule analysis and factor analysis were conducted to reveal the medication rules. Results A total of 7 019 valid medical records and corresponding herbal prescriptions involving 225 herbs were included. Thirty-seven high-frequency herbs （usage frequency＞5%） were identified， and the leading 5 herbs were Atractylodis Macrocephalae Rhizoma， Salviae Miltiorrhizae Radix et Rhizoma，Taxilli Herba，Codonopsis Radix，and Poria，followed by Sparganii Rhizoma， Curcumae Radix， Cuscutae Semen， and Curcumae Rhizoma. The predominant syndrome patterns were qi deficiency with blood stasis， kidney deficiency with blood stasis， and qi stagnation with blood stasis. The medicinals were primarily cold，warm，or neutral in nature，bitter，sweet，or pungent in flavor，and had the meridian tropism of the spleen， liver， and kidney meridians. Most of the herbs had the therapeutic actions of tonifying deficiency and activating blood circulation to resolve stasis. Association rule analysis revealed 14 herbal combinations， and the herbal combinations with the higher support were Atractylodis Macrocephalae RhizomaTaxilli Herba， Atractylodis Macrocephalae Rhizoma-Poria， Atractylodis Macrocephalae Rhizoma-Paeoniae Radix Alba， Curcumae Rhizoma-Sparganii Rhizoma， and Salviae Miltiorrhizae Radix et Rhizoma-Sparganii Rhizoma. Syndrome-herb association rule analysis showed that：（1）Qi deficiency with blood stasis syndrome was highly associated with the ingredients of Shengyu Decoction and herbs of Corydalis Rhizoma， Leonuri Herba， Aurantii Fructus，and Curcumae Radix；（2） Kidney deficiency with blood stasis syndrome was highly associated with the ingredients of Shoutai Pills plus Erzhi Pills and herbs of Mori Fructus， Dioscoreae Rhizoma， and Rehmanniae Radix；（3）Qi stagnation with blood stasis syndrome was highly associated with the ingredients of Danggui Shaoyao San and herbs of Salviae Miltiorrhizae Radix et Rhizoma， Taxilli Herba， and Aucklandiae Radix；（4） Spleen deficiency with dampness-stasis syndrome was highly associated with the ingredients of Shenling Baizhu San and herbs of Sparganii Rhizoma，Curcumae Rhizoma，Astragali Radix，and Galli Gigerii Endothelium Corneum；（5） Cold coagulation with blood stasis syndrome was highly associated with the ingredients of Shaofu Zhuyu Decoction and herbs of Sparganii Rhizoma，Curcumae Rhizoma，Crataegi Fructus，Aucklandiae Radix，and Curcumae Radix. Factor analysis yielded eight common factors，and the cluster analysis showed that high-frequency herbs can be classified into six groups. Conclusion Professor Liang proposes that the core pathogenesis of endometriosis-associated dysmenorrhea is characterized by deficiency and stasis. Therefore，the treatment should follow the principle of tonifying deficiency and resolving stasis， and can be conducted by combining with menstrual cycle-based therapy （promoting blood circulation and removing stasis during menstrual phase， nourishing yin and blood after menstrual phase， activating blood and dredging collaterals to assist ovulation during the intermenstrual phase，and regulating liver qi before menstrual phase），which will effectively alleviate dysmenorrhea in endometriosis patients.

R271.11+3

广东省基础与应用基础研究基金项目（编号：2023A1515220004）；广东省中医药局科研项目（编号：20232058）；广东省中医证候 临床研究重点实验室项目（编号：KF2023ZH05）；广东省中医药防治难治性慢病重点实验室项目（编号：YN2023MB08、YN2023MS39）； 广东省中医药局梁雪芳广东省名中医传承工作室建设项目（粤中医办函（2023）108号）