【目的】 挖掘朱丽华教授采用中药外治法治疗糖尿病足的用药规律。【方法】 收集朱丽华教授2016年1月至2024年1月 期间采用中药外治法治疗糖尿病足患者且有效的外用处方，统计药物的用药频次、性味归经，并采用关联规则分析、聚类 分析、复杂网络分析挖掘核心处方。【结果】 共纳入处方 216首，涉及中药 133味，药物总频次为 1 727次，其中频次居前的 中药为桂枝、川芎、红花、当归、赤芍等。所用药物以温阳化气、疏肝活血、通络止痛为主。药性以温、平、微寒为主； 药味以辛、苦、甘为主；归经以入肝、心、脾经为主。关联规则分析得到二项药物关联规则11条，三项关联规则43条。复 杂网络显示核心处方为桂枝、川芎、红花、赤芍、当归、桃仁、艾叶、柴胡、木瓜、延胡索。【结论】 朱丽华教授采用中药 外治法治疗糖尿病足重在通阳化气、疏肝活血、通络止痛，用药寒温平调，攻邪不忘扶正。

Objective To investigate the medication patterns of Professor Zhu Lihua’s external treatment for diabetic foot （DF） with Chinese herbal medicine. Methods Externally-used prescriptions for DF patients treated effectively by Professor Zhu Lihua from January 2016 to January 2024 were collected. The frequency， nature， flavor，and meridian tropism of the herbs were analyzed. Association rule analysis，cluster analysis，and complex network analysis were employed to identify core prescriptions. Results A total of 216 prescriptions involving 133 herbs with a cumulative frequency of 1 727 were included. The frequently-used herbs were Cinnamomi Ramulus， Chuanxiong Rhizoma，Carthami Flos，Angelicae sinensis Radix，Paeoniae Radix Rubra，etc. The herbs mainly have the actions of warming yang to transform qi， soothing the liver and activating blood circulation， and unblocking collaterals to relieve pain. The herbs were usually warm， neutral， and slightly cold in nature， pungent，bitter，and sweet in flavor，and have the primary meridian tropism of the liver， heart， and spleen meridians. Association rule analysis yielded 11 two-herb combinations and 43 three-herb combinations. Complex network analysis revealed that the core prescription was composed of Cinnamomi Ramulus，Chuanxiong Rhizoma， Carthami Flos，Paeoniae Radix Rubra，Angelicae Sinensis Radix，Persicae Semen，Artemisiae Argyi Folium，Bupleuri Radix，Chaenomelis Fructus，and Corydalis Rhizoma. Conclusion For the treatment of DF with external use of Chinese herbal medicine，Professor Zhu Lihua emphasizes the use of therapies of warming yang to transform qi，soothing the liver and activating blood circulation，and unblocking collaterals to relieve pain. The medication strategy balances cold and warm properties of the herbs，and cares about eliminating pathogens without neglecting the reinforcement of healthy qi.

R259.872

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