【目的】 观察基于子午流注择时理论的耳穴揿针治疗功能性消化不良（FD）伴焦虑抑郁的临床疗效。【方法】 选取 2023 年6月至2024年6月西安市中医医院脾胃病科收治的70例明确诊断为FD伴焦虑抑郁患者为研究对象。按随机数字表将 患者随机分为观察组和对照组，每组各35例。对照组给予给予枸橼酸莫沙必利分散片和氟哌噻吨美利曲辛片治疗。观察组 在对照组治疗的基础上，给予择时耳穴揿针治疗。共治疗4周。治疗1个月后，评价2组临床疗效。观察2组患者治疗前后 中医证候积分的变化情况，以及汉密尔顿抑郁量表（HAMD）评分、汉密尔顿焦虑量表（HAMA）评分的情况。比较2组患者治 疗前后胃肠道生活质量指数（GIQLI）评分的变化情况。【结果】（1）治疗后，2组患者的中医证候积分明显改善（P＜0.05），且 观察组在改善中医证候积分方面明显优于对照组，差异有统计学意义（P＜0.05）。（2）治疗后，2组患者的HAMA、HAMD评分 明显改善（P＜0.05），且观察组在改善 HAMA、HAMD评分方面明显优于对照组，差异有统计学意义（P＜0.05）。（3）治疗后， 2组患者的GIQLI评分明显改善（P＜0.05），且观察组在改善GIQLI评分方面明显优于对照组，差异有统计学意义（P＜0.05）。 （4）观察组总有效率为 91.43%（32/35），对照组为 74.28%（26/35）。观察组疗效优于对照组，差异有统计学意义（P＜0.05）。 【结论】 基于子午流注择时理论的耳穴揿针治疗FD伴焦虑抑郁，能够明显改善患者消化不良的临床症状，缓解患者的焦虑 抑郁情绪，从而提升患者的生活质量，疗效显著。

Objective To observe the clinical efficacy of auricular press needle therapy based on the midnightmidday ebb-flow theory of time selection in treating functional dyspepsia （FD） with anxiety and depression. Methods A total of 70 patients diagnosed with FD accompanied by anxiety and depression who were treated in the Department of Spleen and Stomach Diseases at Xi’an Hospital of Traditional Chinese Medicine between June 2023 and June 2024 were selected as study subjects. Patients were randomly divided into an observation group and a control group using a random number table，with 35 patients in each group. The control group received Mosapride Citrate Dispersible Tablets and Flupentixol-Melitracen Tablets. The observation group received additional timely auricular press needle therapy based on the control group’s treatment. The treatment duration was 4 weeks. After one month of treatment， clinical efficacy was evaluated by observing changes in Traditional Chinese Medicine （TCM） syndrome scores，Hamilton Depression Scale （HAMD） scores，Hamilton Anxiety Scale （HAMA） scores，and Gastrointestinal Quality of Life Index （GIQLI） scores before and after treatment in both groups. Results （1）After treatment，TCM syndrome scores were significantly improved in both groups （P＜0.05），and the improvement in the observation group was significantly greater than that in the control group， the difference being statistically significant （P＜0.05）.（2） After treatment，HAMA and HAMD scores were significantly improved in both groups （P＜0.05），and the improvement in the observation group was significantly greater than that in the control group， the difference being statistically significant （P＜0.05）.（3） After treatment， GIQLI scores were significantly improved in both groups （P＜0.05），and the improvement in the observation group was significantly greater than that in the control group，the difference being statistically significant （P＜0.05）.（4） The total effective rate was 91.43% （32/35） in the observation group and 74.28% （26/35） in the control group. The efficacy of the observation group was significantly superior to that of the control group，the difference being statistically significant （P＜0.05）. Conclusion The auricular press needle therapy based on the midnight-midday ebb-flow theory of time selection significantly improves clinical symptoms of dyspepsia， alleviates anxiety and depression， and enhances the quality of life in patients with FD accompanied by anxiety and depression，demonstrating notable clinical efficacy.

R246.9

陕西省自然科学基金项目（编号：2020JM-699）；陕西省中医药管理局中医重点专科项目（[2012]55号）；西安市中医医院院级项目 （编号：JY202335）