【目的】 探究广东省名中医吴伟教授治疗冠心病的用药规律，为冠心病的中医临床治疗提供参考。【方法】 收集 2015 年 9 月至2024 年9月吴伟教授于广州中医药大学第一附属医院心内科门诊治疗的冠心病有效病例的处方，并将处方数据录入中 医传承辅助系统（V2.5）。通过采用该软件的频次分析、关联规则分析、关联度分析及聚类分析等数据挖掘方法，对处方中药 物的使用频次、药物间的关联规则、潜在新方组合等进行分析。【结果】 共纳入 200 首处方，包含 134 味药物。使用频次在 15次以上的常用药物有 28 味，居前 10位的药物为丹参、赤芍、川芎、降香、毛冬青、红花、黄芩、黄芪、五指毛桃、竹 茹。常用药物的功效归类以活血、清热、补气、补阴、理气药为主。药物的关联规则分析得到27个常用药物组合，主要为 赤芍、丹参、降香、川芎、毛冬青、红花 6味中药的组合。药物间的关联度分析显示，吴伟教授治疗冠心病的处方多以活 血、清热、化痰、补阴、补气、理气、利水、安神等中药相互配伍。基于复杂系统熵聚类的聚类分析得到潜在新方组合 7 个。【结论】 吴伟教授治疗冠心病用药以清热解毒、活血化瘀为主，常佐以补气、化痰、理气、补阴、利水、安神等药， 体现了吴伟教授对冠心病的“热毒血瘀”病机的认识及其重视运用清热活血法的临证经验。

Objective To explore the medication patterns of Professor Wu Wei，a renowned traditional Chinese medicine （TCM） expert of Guangdong Province，in treating coronary heart disease （CHD） and to provide insights for TCM clinical management of CHD. Methods From September 2015 to September 2024，the prescriptions for effective CHD cases treated by Professor Wu Wei at the Department of Cardiology，the First Affiliated Hospital of Guangzhou University of Chinese Medicine were collected. The prescription data were input into the TCM Inheritance Assistant System （V2.5）. Data mining methods of frequency analysis， association rule analysis， association degree analysis， and cluster analysis were employed to analyze the usage frequencies of herbs， association rules among herbs，and potential novel formula combinations. Results A total of 200 prescriptions were included，comprising 134 medicinals. There were 28 herbs used over 15 times. The top 10 most frequently-used herbs were Salviae Miltiorrhizae Radix et Rhizoma，Paeoniae Radix Rubra，Chuanxiong Rhizoma，Dalbergiae Odoriferae Lignum， Ilex Pubescens Radix， Carthami Flos， Scutellariae Radix， Astragali Radix， Fici Simplicissimae Radix，and Bambusae Caulis in Taenia. The commonly-used medicinals can be primarily classified into blood-activating herbs，heat-clearing herbs，qi-tonifying herbs，yin-nourishing herbs，and qi-regulating herbs according to their therapeutic actions. Association rule analysis identified 27 herbal combinations used frequently，predominantly involving Paeoniae Radix Rubra，Salviae Miltiorrhizae Radix et Rhizoma，Dalbergiae Odoriferae Lignum， Chuanxiong Rhizoma， Ilex Pubescens Radix， and Carthami Flos. Association degree analysis revealed that Professor Wu Wei’s prescriptions for CHD usually consisted of the combinations of bloodactivating， heat-clearing， phlegm-resolving， yin-nourishing， qi-tonifying， qi-regulating， diuretic， and sedative herbs. Complex system entropy-based cluster analysis yielded seven potential novel formulas. Conclusion For the treatment of CHD，Professor Wu Wei focuses on the utilization of heat-clearing and toxin-resolving herbs and blood-activating and stasis-resolving agents， and frequently uses qi-tonifying， phlegm-resolving， qiregulating，yin-nourishing，diuretic，and sedative herbs as the adjuvant drugs，which reflects his view of CHD’ s pathogenesis being heat-toxin and blood stasis and his emphasis on the clinical application of heat-clearing and blood-activating therapy.

R259.414

国家自然科学基金面上项目（编号：82074356）