【目的】分析含柴胡-黄芩药对方剂的组方及应用规律。 【方法】以《中医方剂大辞典》为数据来源，筛选含柴胡-黄芩 药对的方剂，采用Excel 2019、SPSS Modeler、Cytoscape等软件探究含柴胡-黄芩药对方剂的组方及应用规律。 【结果】经筛选 后共得到含柴胡-黄芩药对方剂928首，涉及中药293味；除柴胡、黄芩外，甘草、人参、当归、白芍、半夏、栀子、茯苓 等为高频使用的药物，是含柴胡-黄芩药对组方的核心药物。药物配伍以寒性药及苦、辛、甘味药为主，归经以归肝、肺经 为主。关联规则分析结果显示，含柴胡-黄芩药对方剂常配伍使用“半夏-人参-甘草”“茯苓-人参-甘草”药物组合。含柴 胡-黄芩药对方剂可用于治疗184种疾病，其中优势病种为伤寒、热证、眼病。含柴胡-黄芩药对方剂的中药复杂网络分析及 剂量配伍分析显示，治疗伤寒类疾病配伍的核心中药为半夏、人参、栀子、葛根等，治疗热证类疾病配伍的核心中药为赤 芍、黄连、栀子等，治疗眼病类疾病配伍的核心中药为车前子、升麻、决明子等；治疗伤寒、热证、眼病时，柴胡-黄芩药 对的常用配伍剂量比均为1∶1。 【结论】柴胡-黄芩药对配伍具有和解少阳之功，临床可用于治疗多种疾病。通过数据挖掘技 术揭示的含柴胡-黄芩药对方剂的优势病种及用药规律，可为现代临床运用该药对治疗疾病提供参考。

Objective To analyze the composition patterns and indications of formulas containing the herbal pair of Bupleuri Radix and Scutellariae Radix （abbreviated as herbal pair Chaihu-Huangqin） . Methods With Zhong Yi Fang Ji Da Ci Dian （Encyclopedia of Chinese Medicinal Formulas） as the data source，formulas containing herbal pair Chaihu-Huangqin were screened. Excel 2019，SPSS Modeler，and Cytoscape were employed to investigate the composition patterns and indications of the formulas containing the herbal pair. Results A total of 928 formulas containing the herb pair were identified，involving 293 herbs. Beyond Bupleuri Radix and Scutellariae Radix， high-frequency herbs of Glycyrrhizae Radix et Rhizoma，Ginseng Radix et Rhizoma，Angelicae Sinensis Radix， Paeoniae Radix Alba，Pinelliae Rhizoma，Gardeniae Fructus，and Poria are the primary ingredients of formulas containing herbal pair Chaihu-Huangqin. The herbs as the ingredient combinations were predominantly cold in nature and were bitter，pungent，or sweet in flavors，primarily acting on the liver and lung meridians. Association rule analysis revealed that herbal pair Chaihu-Huangqin was frequently use together with herbal groups of “Pinelliae Rhizoma-Ginseng Radix et Rhizoma-Glycyrrhizae Radix et Rhizoma” and “Poria-Ginseng Radix et Rhizoma-Glycyrrhizae Radix et Rhizoma” . Formulas containing herbal pair Chaihu-Huangqin were indicated for 184 kinds of diseases， in particular for exogenous febrile diseases， heat syndrome， and ocular disorders. Complex network analysis and dosage analysis indicated that common combined herbs of Pinelliae Rhizoma， Ginseng Radix et Rhizoma，Gardeniae Fructus，and Puerariae Lobatae Radix were indicated for exogenous febrile diseases；common combined herbs of Paeoniae Radix Rubra，Coptidis Rhizoma，and Gardeniae Fructus were indicated for heat syndrome；and common combined herbs of Plantaginis Semen，Cimicifugae Rhizoma，and Cassiae Semen were indicated for ocular disorders. The dosage ratio of Bupleuri Radix-Scutellariae Radix consistently maintained a 1∶1 ratio across all above indications. Conclusion The herbal pair Chaihu-Huangqin functions to harmonize shaoyang meridian and demonstrates broad clinical applicability. The data mining study has revealed its dominant indications and combinatorial patterns， which will provide evidence-based insights for modern clinical practice.

R289.1

山西省基础研究计划项目自然科学研究面上项目 （编号：202303021211173） ；长春中医药大学附属医院基本中医药循证能力建设 项目 （2023）