低钾性周期性麻痹是一种非常罕见但可能危及生命的疾病，常突然发作，且伴有饱食、剧烈运动等诱因，加大了疾 病预防和治疗的难度，严重影响了患者的生活质量。随着现代中医对脾主运化水液、肾主封藏理论的深入研究以及西医对 疾病微观认知的进一步加深，发现中医可借助现代医学微观生理病理的认知来阐释疾病的病机变化，有助于建立疾病高危 因素的中医管理模式。该文从脾肾相关角度揭示血钾平衡与低钾性周期性麻痹的联系，认为脾失健运、肾失封藏，可致血 钾失衡，进而诱发低钾性周期性麻痹，二者为其重要病机；其防治当在健运中焦的基础上，兼顾填精固肾，临床应用补中 益气汤合大补阴丸加减治疗可取得较好疗效。基于血钾平衡从脾肾相关探讨低钾性周期性麻痹的辨治，可为其中医防治提 供新的思路。

Hypokalemic periodic paralysis （HypoPP） is a very rare but potentially life-threatening condition， often attacking suddenly， usually triggered by overeating or vigorous exercise， which complicates disease prevention and treatment and significantly lowers patients’ quality of life. With the deepening of modern traditional Chinese medicine （TCM） research on the spleen’ s role in water metabolism and the kidney’ s function in storage， and with the achievements in western medicine’ s microscopic understanding of the disease，it has been found that TCM can utilize the micro-level physiological and pathological insights of modern medicine to elucidate the pathogenesis of diseases，thereby facilitating the establishment of a TCM management model for high-risk factors of diseases. This article explored the relationship between potassium balance and HypoPP from the perspective of spleen-kidney correlation. It is proposed that spleen failing in transportation and kidney failing in storing essence may lead to potassium imbalance，which constitutes a key pathogenesis of HypoPP. Prevention and treatment should focus on strengthening the middle energizer and simultaneously reinforcing kidney essence. Clinically， modified Buzhong Yiqi Decoction plus Da Buyin Pills has shown favorable therapeutic effects. The approach of making diagnosis and treatment of HypoPP based on potassium balance and from the perspective of spleen-kidney correlation may provide novel insights for its TCM prevention and management.

R259.911

辽宁省教育厅基本科研项目 （编号：L202007） ；辽宁省名中医传承工作室建设项目 （编号：2022-1） ；沈阳市临床医学研究中心 项目 （沈科发[2018]7-5号）