【目的】观察氟哌啶醇联合耳穴贴压治疗儿童抽动障碍的临床疗效。 【方法】选择2022年3月至2024年3月河北省沧州 中西医结合医院儿童康复科收治的120例明确诊断为抽动障碍的患儿为研究对象。按随机数字表将患儿随机分为观察组和对 照组，每组各60例。对照组给予氟哌啶醇治疗，观察组在对照组治疗的基础上，给予耳穴贴压治疗。共治疗12周。治疗 3个月后，评价2组临床疗效。观察2组患者治疗前后耶鲁综合抽动严重程度量表 （YGTSS） 评分的变化情况，以及5-羟色胺 （5-HT） 、多巴胺 （DA） 含量的情况。比较2组患者治疗前后免疫功能指标T淋巴细胞CD3+ 、CD4+ 的变化情况。并评价2组 的安全性及不良反应的发生情况。 【结果】（1） 观察组总有效率为91.67% （55/60） ，对照组为76.67% （46/60） 。观察组疗效优于 对照组，差异有统计学意义 （P＜0.05） 。 （2） 治疗后，2组患儿YGTSS评分明显改善 （P＜0.05） ，且观察组在改善YGTSS评分方 面明显优于对照组，差异有统计学意义 （P＜0.05） 。 （3） 治疗后，2组患儿5-HT、DA含量明显改善 （P＜0.05） ，且观察组在改 善5-HT、DA含量方面明显优于对照组，差异有统计学意义 （P＜0.05） 。 （4） 治疗后，2组患儿CD3+ 、CD4+ 明显改善 （P＜ 0.05） ，且观察组在改善CD3+ 、CD4+ 方面明显优于对照组，差异有统计学意义 （P＜0.05） 。 （5） 观察组与对照组的不良反应发生 率比较，差异无统计学意义 （P＞0.05） 。 【结论】氟哌啶醇联合耳穴贴压治疗儿童抽动障碍，能明显改善患儿临床症状，提高 患儿的免疫功能，且安全性好，疗效显著。

Objective To evaluate the clinical efficacy of haloperidol combined with auricular point pressing therapy in children with tic disorders. Methods A total of 120 pediatric patients diagnosed with tic disorders at the Department of Pediatric Rehabilitation， Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine，Hebei Province from March 2022 to March 2024 were enrolled. Participants were randomly divided into an observation group （n=60） and a control group （n=60） using a random number table. The control group received haloperidol alone，while the observation group received additional auricular point pressing therapy. Treatment duration was 12 weeks. After 3 months，clinical efficacy was assessed by comparing：Yale Global Tic Severity Scale （YGTSS） scores， serum 5-hydroxytryptamine （5-HT） and dopamine （DA） levels， immune function markers （CD3+ ，CD4+ ） ，and incidence of adverse reactions between groups. Results （1） The overall efficacy rate in the observation group was 91.67% （55/60） ，while that in the control group was 76.67% （46/60） . The efficacy of the observation group was superior to that of the control group，with a statistically significant difference （P＜0.05） . （2） After treatment，the YGTSS scores of children in both groups was significantly improved （P＜0.05） ，and the observation group showed a significantly greater improvement in YGTSS scores than the control group，with a statistically significant difference （P＜0.05） . （3） After treatment，the levels of 5-HT and DA in both groups of children were significantly improved （P＜0.05）， and the observation group showed a significantly greater improvement in 5-HT and DA levels than the control group，with a statistically significant difference （P＜0.05） . （4） After treatment，CD3+ and CD4+ levels were significantly improved in both groups （P＜0.05），and the observation group showed a significantly greater improvement in CD3+ and CD4+ levels than the control group，with a statistically significant difference （P＜0.05） . （5） There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group，with a statistically significant difference （P＞0.05） . Conclusion The combination of haloperidol and auricular point pressing therapy significantly improves clinical symptoms and immune function in children with tic disorders，demonstrating both efficacy and safety.

R246.9

河北省中医药管理局科研计划项目 （编号：2021312）