【目的】 基于数据挖掘技术和文献整理探析张景岳安胎的用药规律和诊疗特色。【方法】 收集《景岳全书·妇人规》“胎 孕类”篇中安胎方的方药信息，建立数据库。利用SPSS Modeler 18.0、SPSS Statistics 26.0等软件对安胎方剂药物进行频次分 析、关联分析和聚类分析，探讨张景岳安胎的用药规律。通过整理“胎孕类”篇中有关安胎的论述，探讨张景岳安胎的诊 疗特色。【结果】 共获得安胎方剂76首，涉及中药102味。使用频次 ≥ 5次的高频中药共26味；其功效分类以补虚药为主，共 11味。药物关联分析得到“白术→人参”“炙甘草→人参、白术”等支持度较高的10个药物关联规则，药物关联网状图得到 炙甘草、白术、茯苓、人参、当归等关联度较高的药物。聚类分析得到“酸枣仁、远志、山药、山茱萸”“白芍、川芎、熟 地黄、白术、人参、炙甘草、当归、茯苓、陈皮”“地黄、甘草、黄芩”“半夏、厚朴、生姜、大枣”4首核心处方。张景岳 安胎之诊疗特点如下：治病与安胎并举，分月养胎以预培其损，稳固胎元以调养母体为主，重视妊娠期间的药食禁忌及生 活起居。【结论】 张景岳安胎主张审病求因，治病与安胎并举；以补益气血为法，善于调补脾胃、疏利气机，用药精专平和， 组方精简灵活。其用药规律和诊疗特点可为现代安胎治疗提供一定的借鉴。

Objective To explore the medication rules and therapeutic principles of Zhang Jingyue’s miscarriage prevention therapies based on data mining technique and literature analysis. Methods The prescription data recorded in the chapter about pregnancy and fetal development from the volume of Women’s Diseases in Jing Yue Quan Shu（Jingyue’s Complete Works） were collected to establish a database. Frequency analysis，association analysis， and cluster analysis of the herbal medicines from the prescriptions for preventing miscarriage were performed using SPSS Modeler 18.0 and SPSS Statistics 26.0 to investigate Zhang’s medication rules. Additionally， discussions on miscarriage prevention in the chapter about pregnancy and fetal development were systematically reviewed to summarize his therapeutic principles. Results A total of 76 miscarriage-prevention prescriptions involving 102 herbal medicinals were analyzed. Among them，26 high-frequency herbal medicinals （used ≥ 5 times） were identified，and primarily belonged to the tonifying deficiency category （11 medicinals）. Association analysis revealed 10 association rules with high support，such as “Atractylodis Macrocephalae Rhizoma→Ginseng Radix et Rhizoma” and “Glycyrrhizae Radix et Rhizoma Praeparata cum Melle→Ginseng Radix et Rhizoma，Atractylodis Macrocephalae Rhizoma”. The network graph of drug association presented high-correlation herbs including Glycyrrhizae Radix et Rhizoma Praeparata cum Melle， Atractylodis Macrocephalae Rhizoma， Poria， Ginseng Radix et Rhizoma，and Angelicae Sinensis Radix. Cluster analysis yielded four core prescription groups：（1）Ziziphi Spinosae Semen， Polygalae Radix， Dioscoreae Rhizoma， and Corni Fructus；（2） Paeoniae Radix Alba， Chuanxiong Rhizoma，Rehmanniae Radix Praeparata，Atractylodis Macrocephalae Rhizoma，Ginseng Radix et Rhizoma，Glycyrrhizae Radix et Rhizoma Praeparata cum Melle，Angelicae Sinensis Radix，Poria，and Citri Reticulatae Pericarpium；（3） Rehmanniae Radix， Glycyrrhizae Radix et Rhizoma， and Scutellariae Radix； （4）Pinelliae Rhizoma，Magnoliae Officinalis Cortex，Zingiberis Rhizoma Recens，and Jujubae Fructus. Zhang’s therapeutic principles for preventing miscarriage were as follows：（1） treating primary diseases together by preventing miscarriage；（2） monthly-specific cultivation of the fetus to preemptively address deficiencies； （3） emphasis on maternal health to consolidate fetal vitality；（4） strict adherence to medication and dietary contraindications and lifestyle management during pregnancy. Conclusion Zhang Jingyue’s miscarriage-prevention principles emphasize etiological diagnosis with dual focus on treating primary diseases and preventing miscarriage. His therapies prioritize replenishing qi and blood，skillfully regulating spleen-stomach function and qi movement by employing special and mild herbs and prescribing simplified and flexible formulas. These medication rules and therapeutic principles may provide valuable references for modern miscarriage-prevention strategies.

R249.8

国家卫生健康委医药卫生科技发展项目（编号：WKZX2024DN0133）；东莞市社会发展科技项目（编号：20231800900283， 20231800907991）