【目的】 对近20年有关四君子汤研究的国内外相关文献进行计量学分析，探讨四君子汤研究现状、研究热点、发展趋 势。【方法】 检索中国知网（CNKI）、万方（Wanfang）、维普（VIP）和Web of Science数据库，收集2004-2024年期间有关四君子 汤研究的期刊文献，采用Microsoft Excel进行文献的发文量分析；运用CiteSpace软件进行关键词的共现分析、聚类分析及突 现分析，并对分析结果进行可视化。【结果】 经文献检索和筛选后，共纳入中文文献 3 573篇和英文文献 113篇。近 20年来， 发文量总体呈稳定增长趋势。有关四君子汤研究的中、英文文献中，出现频次最高的关键词分别为脾虚证和基因表达，爆 发强度最高的关键词为实验研究和数据挖掘。【结论】 近20年来四君子汤的主要研究类型为动物实验和临床应用，研究热点 集中在脾虚证相关疾病的治疗以及对癌症患者免疫功能的改善，预测其研究趋势包括四君子汤活性成分的提取、鉴定以及 对脾虚证相关疾病作用机制的研究。

Objective To conduct a bibliometric analysis of domestic and international literature on the research of Sijunzi Decoction over the past 20 years，and to explore the research status，hotspots，and development trends of Sijunzi Decoction. Methods This article retrieved journal articles related to the research of Sijunzi Decoction from 2004 to 2024 in the CNKI， Wanfang， VIP， and Web of Science databases. Microsoft Excel was used for publication volume analysis，while CiteSpace software was employed for keyword co-occurrence，clustering，and burst analysis， and then the analysis results were visualized. Results After literature retrieval and screening， 3 573 Chinese articles and 113 English articles were included. Over the past two decades，the publication volume showed a trend of steadily increasing. The most frequent keywords in Chinese and English literature on the research of Sijunzi Decoction were spleen deficiency syndrome and gene expression，while the keywords with strongest burst were experimental research and data mining. Conclusion The research of Sijunzi Decoction in the last 20 years was mainly through animal experiments and clinical applications，and the research hotspots focus on the treatment of diseases of spleen deficiency syndrome and on the improvement of immune function of cancer patients. The extraction and identification of active components in Sijunzi Decoction and the study on the therapeutic mechanism in diseases of spleen deficiency syndrome are probably the future research trends.

R289.5

江苏省中医药科技发展计划项目（编号：MS2023180）；江苏省高校基础科学（自然科学）研究重大项目（编号：24KJA360001）