【目的】 采用数据挖掘的方法分析全国名老中医黄枫教授治疗骨髓炎的处方用药规律。【方法】 收集和筛选黄枫教授于 2018年 1月至 2022年 12月期间治疗骨髓炎的有效病历的处方资料，利用 Microsoft Excel、SPSS Modeler 18.0、SPSS Statistics 25软件对处方用药进行频次、性味归经分布规律分析，并对高频药物进行关联规则分析和聚类分析。【结果】 共纳入137首处 方，涉及中药86味。其中频次＞30次的高频药物共有18味，分别为甘草、黄芪、薏苡仁、当归、土茯苓、牛膝、白及、地 黄、白芍、石斛、远志、白扁豆、延胡索、白芷、骨碎补、地榆、茯苓、乌梅。处方药物以平性药物居多，药味分布以甘、 苦、辛为主，用药多归肝、脾、肺经。关联规则分析得到67条药物关联规则，支持度较高的药物组合为黄芪与薏苡仁、当 归、土茯苓、牛膝等药物的配伍使用，体现了补益气血、活血化瘀、利湿解毒的药物配伍原则。聚类分析得到3个核心聚类 组合。聚类1的药物组合为甘草、黄芪、薏苡仁、土茯苓、当归、白及、白芍、白芷、乌梅、远志、地榆；聚类2的药物组 合为地黄、石斛；聚类3的药物组合为牛膝、白扁豆、延胡索、茯苓。【结论】 黄枫教授治疗骨髓炎的用药以扶正与祛邪相结 合为原则，以祛除湿热毒邪为主，兼顾活血化瘀，并强调因地制宜，重视健运脾胃以扶正。

Objective To analyze the prescription patterns of Professor Huang Feng， a nationally renowned traditional Chinese medicine （TCM） practitioner，in treating osteomyelitis using data mining methods. Methods Prescription data from effective medical records of osteomyelitis treated by Professor Huang Feng between January 2018 and December 2022 were collected and screened. Microsoft Excel，SPSS Modeler 18.0，and SPSS Statistics 25 were used to analyze the frequency and the distribution of properties， flavors， and meridian tropism of prescribed medications，along with association rule analysis and cluster analysis of high-frequency drugs. Results A total of 137 prescriptions involving 86 Chinese medicinals were included. Eighteen high-frequency medicinals （frequency＞30 times） were identified，namely Glycyrrhizae Radix et Rhizoma，Astragali Radix，Coicis Semen， Angelicae Sinensis Radix， Smilacis Glabrae Rhizoma， Achyranthis Bidentatae Radix， Bletillae Rhizoma， Rehmanniae Radix， Paeoniae Radix Alba， Dendrobii Caulis， Polygalae Radix， Lablab Semen Album， Corydalis Rhizoma，Angelicae Dahuricae Radix，Drynariae Rhizoma，Sanguisorbae Radix，Poria，and Mume Fructus. Most of the prescribed medicinals were neutral in nature，sweet，bitter，and pungent in flavor，and had the meridian tropism of liver，spleen，and lung meridians. Association rule analysis yielded 67 drug association rules，and the high-support combinations were the drug combinations of Astragali Radix respectively with Coicis Semen，Angelicae Sinensis Radix，Smilacis Glabrae Rhizoma and Achyranthis Bidentatae Radix，reflecting the compatibility principles of supplementing and invigorating qi-blood，activating blood circulation to resolve stasis， and draining dampness to remove toxins. Cluster analysis revealed three core clusters： Cluster 1 consisted of Glycyrrhizae Radix et Rhizoma，Astragali Radix，Coicis Semen，Smilacis Glabrae Rhizoma，Angelicae Sinensis Radix，Bletillae Rhizoma，Paeoniae Radix Alba，Angelicae Dahuricae Radix，Mume Fructus，Polygalae Radix and Sanguisorbae Radix；Cluster 2 consisted of Rehmanniae Radix and Dendrobii Caulis；Cluster 3 consisted of Achyranthis Bidentatae Radix， Lablab Semen Album， Corydalis Rhizoma and Poria. Conclusion For the treatment of osteomyelitis， Professor Huang Feng follows the principle of combining supporting healthy qi with eliminating pathogens， focuses on clearing damp-heat and pathogenic toxins accompanied by activating blood circulation to resolve stasis， and lays stress on adaptation to local condition and activating spleen-stomach to reinforce vital qi.

R274.9

广州市校（院）企联合资助项目（编号：2025A203J3892）；黄枫全国名老中医传承工作室建设项目（国中医人教函【2022】75号）