【目的】 基于数据挖掘及网络药理学探讨喉咽反流（LPRD）患者的中药处方用药规律及潜在作用机制。【方法】 收集 2012年2月1日至 2023年12月30日期间在广东省中医院门诊就诊的1 016例LPRD患者数据，进行有效中药处方中的药物频 数、四气五味、归经、药物功效分析及关联分析、聚类分析，得出中药治疗LPRD的用药规律，筛选核心中药，再通过网络 药理学方法探讨其作用机制。【结果】 共收录 1 976首处方，涉及 139味中药，共 23 644味次。使用频率前 5位药物分别为甘 草、茯苓、陈皮、僵蚕、鸡内金。中药以甘、平为主，多归肺经，多用补虚药、化痰药，“甘草-陈皮-茯苓”为治疗LPRD 的核心药物。对核心中药“甘草-陈皮-茯苓”进行网络药理学分析，共获取核心中药与 LPRD 的交集靶点 11 个，关键靶 点 3 个，核心药物可能通过白细胞介素 17（IL-17）信号通路、肿瘤坏死因子（TNF）信号通路、癌症通路等改善 LPRD。 【结论】 对于LPRD患者的中药治疗，应从肺入手，用药性味多平甘，功效以补益为主，兼以化痰。核心中药“甘草-陈皮- 茯苓”可能通过 IL-1B、TNF、IL-6 等靶点，调控 IL-17 信号通路、TNF 信号通路、癌症通路等信号通路，减轻炎症反应， 治疗LPRD。

Objective To investigate the prescription patterns and potential therapeutic mechanisms of traditional Chinese medicine （TCM） in treating laryngopharyngeal reflux disease （LPRD） based on data mining and network pharmacology. Methods The clinical data from 1 016 LPRD patients treated at the Guangdong Provincial Hospital of Chinese Medicine between February 1，2012，and December 30，2023 were collected . Frequency analysis， property and flavor analysis， meridian tropism analysis， efficacy classification， association rule mining， and cluster analysis were performed on the effective TCM prescriptions to identify medication rules. Core herbs were screened ， and their therapeutic mechanisms were explored using network pharmacology. Results A total of 1 976 prescriptions involving 139 medicinals （23 644 medicinal frequencies） were analyzed. The top five most frequently-used medicinals were Glycyrrhizae Radix et Rhizoma （Gancao），Poria （Fuling），Citri Reticulatae Pericarpium （Chenpi），Bombyx Batryticatus （Jiangcan），and Galli Gigerii Endothelium Corneum （Jineijin）. The herbs predominantly exhibited sweet flavor and neutral property，with a primary affinity for the lung meridian. The most common therapeutic categories were deficiency-tonifying herbs and phlegm-resolving herbs. The herb combination “Gancao-Chenpi-Fuling” was identified as the core prescription for LPRD. Network pharmacology analysis of this combination revealed 11 shared targets between the core herbs and LPRD，including three key targets. The core herbs may alleviate LPRD by modulating the interleukin-17（IL-17） signaling pathway，tumor necrosis factor （TNF） signaling pathway， and cancer-related pathways. Conclusion TCM treatment for LPRD should primarily target the lung， and employs herbs with mild-sweet properties and tonifying effects， supplemented by phlegm-resolving herbs. The core combination “Gancao-Chenpi-Fuling” may exert therapeutic effects by regulating key targets such as IL-1B， TNF， and IL-6， thereby modulating the IL-17 signaling pathway，TNF signaling pathway，and cancer-related pathways to mitigate inflammatory responses in LPRD.

R276.1

国家自然科学基金项目（编号：82205204)；国家中医药管理局高水平中医药重点学科（中医耳鼻喉科学）建设项目（编号： zyyzdxk-2023163）；广州市科技计划项目（编号：2023B03J0301）；广东省中医证候临床研究重点实验室青年开放课题(编号：KF2023ZH12)； 广东省中医院与香港中文大学医学院生物医学学院基础临床协同创新计划项目（编号：YN2024HK07）；广东省中医院中医药科学技术研究 专项（编号：2020KT1582）