【目的】 观察毓麟珠加减联合梅花针叩刺治疗肾阳亏虚型排卵障碍性不孕（ODI）的临床疗效。【方法】 选取2023年1月 至2024年1月衡水市中医医院收治的100例明确诊断为ODI的患者为研究对象。按照随机数字表将患者随机分为观察组和对 照组，每组各50例。对照组给予西医常规治疗，观察组在对照组治疗的基础上，给予毓麟珠加减方口服并联合梅花针叩刺 治疗。1个月经周期为1个疗程，共持续治疗3个月经周期。治疗3个月后，评价2组临床疗效。观察2组患者治疗前后中医 证候积分的变化情况，以及排卵率、妊娠率及A型子宫内膜的情况。比较2组患者治疗前后卵巢体积和窦卵泡数量的变化情 况，并评价2组的安全性及不良反应的发生情况。【结果】（1）治疗后，2组患者的中医证候积分明显改善（P＜0.05），且观察 组在改善中医证候积分方面明显优于对照组，差异有统计学意义（P＜0.05）。（2）观察组总有效率为90.00%（45/50），对照组为 72.00%（36/50）。观察组疗效优于对照组，差异有统计学意义（P＜0.05）。（3）观察组排卵率、妊娠率、A型子宫内膜比例均明 显优于对照组，差异有统计学意义（P＜0.05）。（4）治疗后，2组患者的卵巢体积和窦卵泡数量明显改善（P＜0.05），且观察组 在改善卵巢体积和窦卵泡数量方面明显优于对照组，差异有统计学意义（P＜0.05）。（5）观察组不良反应发生率为8.00%（4/50）， 对照组为24.00%（12/50）。观察组的不良反应发生率明显低于对照组，差异有统计学意义（P＜0.05）。【结论】 毓麟珠加减联合 梅花针叩刺治疗肾阳亏虚型 ODI，能够有效改善患者的临床症状，提高排卵率、妊娠率和 A 型子宫内膜数量，缩小卵巢体 积，减少窦卵泡数量，提高临床疗效，减少不良反应。

Objective To evaluate the clinical efficacy of modified Yulinzhu Formula combined with plum-blossom needle tapping acupuncture in treating kidney-yang deficiency type of ovulatory dysfunction infertility （ODI）. Methods A total of 100 ODI patients diagnosed at Hengshui Hospital of Traditional Chinese Medicine between January 2023 and January 2024 were enrolled and randomly divided into an observation group and a control group using a random number table， with 50 cases in each group. The control group received conventional western medical treatment， while the observation group received additional oral administration of modified Yulinzhu Formula and plum-blossom needle tapping acupuncture therapy. Treatment was administered for one menstrual cycle as a course，with three consecutive courses completed. After three months，clinical efficacy was assessed by comparing traditional Chinese medicine （TCM） syndrome scores，ovulation rate，pregnancy rate，proportion of type A endometrium， ovarian volume， antral follicle count （AFC）， and adverse reactions between groups. Results （1） After treatment，the scores of TCM syndromes in the two groups were significantly improved （P＜ 0.05），and the improvement in the observation group was superior to that in the control group，the difference being significant （P＜0.05）.（2） The total effective rate was 90.00% （45/50） in the observation group and 72.00% （36/50） in the control group. The curative effect of the observation group was superior to that of the control group， and the difference was statistically significant （P＜0.05）. （3） The ovulation rate， pregnancy rate and the proportion of type A endometrium in the observation group were significantly superior to those in the control group， and the differences were statistically significant （P＜0.05）.（4） After treatment， the ovarian volume and the number of antral follicles in the two groups were significantly improved （P＜0.05 ），and the improvement in the ovarian volume and the number of antral follicles in the observation group was superior to that in the control group， the difference being significant （P＜0.05）.（5） The incidence of adverse reactions was 8.00% （4/50） in the observation group and 24.00% （12/50） in the control group. The incidence of adverse reactions in the observation group was significantly lower than that in the control group，the difference was statistically significant （P＜0.05）. Conclusion Modified Yulinzhu Formula combined with plum-blossom needle tapping acupuncture effectively improves clinical symptoms， enhances ovulation/pregnancy rates， increases type A endometrium， optimizes ovarian volume and AFC，and reduces adverse reactions in kidney-yang deficiency ODI patients.

R246.9

河北省中医药管理局资助项目（编号：2024505）