【目的】 观察壮骨抗松膏与经皮椎体成形术（PVP）联合应用在治疗骨质疏松性椎体压缩骨折（OVCF）方面的临床疗效。 【方法】 选取2023年1月至2024年5月广州市中西医结合医院收治的符合纳入标准的90例OVCF患者，采用随机数字表法将 患者随机分为观察组和对照组，每组各45例。2组均采用PVP手术治疗，对照组患者术后给予常规西药治疗（碳酸钙D3片+ 骨化三醇软胶囊），观察组在对照组的基础上给予服用壮骨抗松膏治疗，其中西药治疗6个月，中药治疗3个月。观察2组患 者治疗前后疼痛视觉模拟量表（VAS）评分、腰背部 Oswestry功能障碍指数（ODI）评分、骨密度 T值及血清骨代谢标志物的变 化情况。【结果】（1）术后第3天和3个月、6个月，2组患者的疼痛VAS评分和腰背部ODI评分均较术前改善（P＜0.05），且观 察组在术后3个月和6个月对疼痛VAS评分和腰背部ODI评分的改善作用均明显优于对照组（P＜0.05）。（2）术后3个月、6个 月和12个月，2组患者的骨密度T值均较术前改善（P＜0.05），且观察组在术后6个月和12个月对骨密度T值的改善作用均明 显优于对照组（P＜0.05）。（3）术后 1个月、3个月和 6个月，2组患者的血清 N-端骨钙素和 25羟维生素 D3[25（OH）D3]水平均 较术前升高（P＜0.05），观察组在术后 3 个月和 6 个月对血清 N-端骨钙素和 25（OH）D3 水平的升高作用均明显优于对照组 （P＜0.05）。【结论】 壮骨抗松膏与PVP联合应用在治疗OVCF方面表现出显著的效果，不仅能有效缓解患者的疼痛，还能提 升骨密度和改善患者日常生活能力，具有较高的临床应用价值。

Objective To evaluate the clinical efficacy of Zhuanggu Kangsong Soft Extract combined with percutaneous vertebroplasty （PVP） in the treatment of osteoporotic vertebral compression fractures （OVCF）. Methods A total of 90 eligible OVCF patients admitted to Guangzhou Integrated Chinese and Western Medicine Hospital between January 2023 and May 2024 were enrolled and randomly divided into an observation group （n= 45） and a control group （n=45） using a random number table. Both groups underwent PVP. After treatment，the control group received conventional western medication orally （calcium carbonate D3 tablets + calcitriol soft capsules）， while the observation group received additional Zhuanggu Kangsong Soft Extract treatment orally. Western medication was administered for 6 months， and herbal treatment lasted 3 months. Changes in Visual Analogue Scale （VAS） scores for pain， Oswestry Disability Index （ODI） scores for low back function， bone mineral density （BMD） T-values，and serum bone metabolism markers were observed before and after treatment. Results（1） At postoperative day 3，3 months，and 6 months，both groups showed significant improvements in VAS and ODI scores compared to those before treatment （P＜0.05）. The observation group demonstrated superior improvements in VAS and ODI scores at 3 and 6 months compared to the control group （P＜0.05）.（2） At 3，6， and 12 months postoperatively， BMD T-values were improved in both groups （P＜0.05），with the observation group exhibiting greater improvements at 6 and 12 months （P＜0.05）.（3） Serum N-terminal osteocalcin and 25- hydroxyvitamin D3 [25（OH）D3] levels increased in both groups at 1， 3， and 6 months （P＜0.05）. The observation group showed more pronounced elevations in these markers at 3 and 6 months （P＜0.05）. Conclusion The combination of Zhuanggu Kangsong Soft Extract and PVP demonstrates significant therapeutic benefits for OVCF by effectively alleviating pain，enhancing BMD，and improving activities of daily living，which highlights its high clinical value.

R274.9

广东省中医药局科研项目（编号：20242071）；广州市卫健委科研项目[编号：1010011920（2100601）]；广州市花都区科技工业与 信息化局科研项目（编号：22-HDWS-069）