【目的】 基于中医运气学说，探究癫痫发病的运气特征规律。【方法】 以英国22个社区自然人群队列研究（UK Biobank） 中确诊为癫痫的8 389例患者为研究对象，采用频数和构成比对癫痫发作的五运六气要素进行描述分析，并采用卡方检验进 行统计学推断。【结果】 分析发现，癫痫患者发病在不同天干、地支、重组岁运、司天在泉及主气分布上存在统计学差异（均 P＜0.05）。其中，从运分析，己、亥年发病最多，丙、卯年发病最少；木运之年、风象之年发病最多，而寒象之年发病最 少，提示癫痫病位在肝。从气分析，主气以三之气少阳相火最多；司天在泉以太阴湿土司天-太阳寒水在泉年份发病最多， 阳明燥金司天-少阴君火在泉年份最少，提示寒湿年份及暑夏之际是癫痫诱发因素。【结论】 癫痫患者发病在运气方面存在一 定规律性，可指导疾病预防与临床诊治。

Objective To investigate the characteristics of epilepsy onset based on the theory of five circuits and six qi in traditional Chinese medicine （TCM）. Methods A total of 8 389 epilepsy patients from a community-based natural population cohort study from UK Biobank were included. Frequency and constituent ratio analyses were performed to describe the distribution of epilepsy onset in relation to the five circuits and six qi elements，and statistical inferences were made using chi-square tests. Results The analysis revealed statistically significant differences existed in epilepsy onset across different heavenly stems， earthly branches， recombinant yearly circuit，celestial control and terrestrial effect，and dominant qi（all P＜0.05）. From the perspective of circuits， the highest incidence occurred in years corresponding to the “Ji” and “Hai” years，while the lowest incidence was observed in “Bing” and “Mao” years. Years dominated by wood circuit and wind manifestations exhibited the highest incidence，whereas years with cold manifestations showed the lowest incidence，suggesting the liver as the primary pathological site in epilepsy. From the perspective of qi， the third dominant qi was most frequently associated with onset. Regarding presiding and subordinate qi，years with taiyin damp earth presiding and taiyang cold water subordinate had the highest incidence，while years with yangming dry metal presiding and shaoyang monarch fire subordinate had the lowest incidence，indicating that cold-damp years and midsummer periods are potential triggers for epilepsy. Conclusion There is a certain regularity in the epilepsy onset correlated with the features of five circuits and six qi，which can guide prevention and clinical diagnosis and treatment of epilepsy.

R277.7

国家自然科学基金面上项目（编号：82374064）