【目的】 运用五运六气原理分析先天性心脏病（CHD）患者胚胎早期和胎孕期运气规律，从运气角度探讨CHD的病因病 机。【方法】 以 16 400例非 CHD人群为对照（健康组），对 4 100例 CHD患者（先心组）胚胎早期和胎孕期的运气特点进行统计 学分析。【结果】 胚胎早期岁运处于火运太过、胚胎早期岁气处于太阳寒水司天-太阴湿土在泉、胎孕期岁运处于火运太过- 土运不及、胎孕期岁气处于太阴湿土在泉-厥阴风木司天为CHD重要易患因素，差异均有统计学意义（P＜0.05或P＜0.01）。 【结论】 胚胎发育期运气禀赋与CHD发病有一定的相关性；CHD的核心病机以心肾不足为本，心火亢而肾水寒为标，脾虚不 运是CHD发生发展的重要推动因素。

Objective To analyze the circuit-qi patterns during early embryonic period and at conception in congenital heart disease（CHD） patients based on the five-circuit and six-qi theory， and to explore the pathogenesis and etiology of CHD from a circuit-qi perspective. Methods With 16 400 non-CHD individuals as the healthy control group，a statistical analysis was performed for the circuit-qi patterns during early embryogenesis and at conception in 4 100 CHD patients（CHD group）. Results The following factors were identified as significant predisposing factors for CHD： yearly circuit being excessive fire circuit during early embryogenesis， yearly qi being taiyang cold water of celestial qi combined with taiyin damp earth of terrestrial qi during early embryogenesis， yearly circuit being concurrent excessive fire circuit and earth circuit deficiency at conception，and yearly qi being taiyin damp earth of terrestrial qi paired with jueyin wind wood of celestial qi at conception（all P＜0.05 or P＜ 0.01）. Conclusion There is a certain correlation between circuit-qi endowment during embryonic development and the prevalence of CHD. The core pathogenesis of CHD is rooted in heart-spleen insufficiency，with hyperactive heart-fire and cold kidney-water as its manifestations，and spleen deficiency failing in transportation serves as an important contributing factor in the development and progression of CHD.

R259.411

国家重点研发计划项目（编号：2022YFC3500103，2022YFC3500100）；广东省基础与应用基础基金项目（编号：2021A1515220046； 2023A1515220070）