缺血性脑卒中是一种由于脑部血管阻塞导致脑组织缺血和缺氧的疾病，该病以局部性神经功能缺失为特征。从病理 学层面剖析，梗死区域的神经元坏死，以及缺血半暗带区域神经元发生变性乃至延迟性死亡，构成了该病的形态学基础。 缺血性脑卒中受铁死亡、细胞凋亡和自噬等多种过程的调控。铁死亡是一种与铁元素密切相关的细胞死亡方式，它与缺血 性脑卒中密切相关。核因子E2相关因子2（Nrf2）是一个关键的转录因子，在维持细胞内的氧化还原平衡和调控炎症反应中起 着重要作用。Nrf2能够促进溶质载体家族7成员11（SLC7A11）和谷胱甘肽过氧化物酶4（GPX4）的表达，从而激活Nrf2信号通 路，对抗铁死亡，保护细胞免受损伤。该文对近年来中医药通过调节Nrf2/SLC7A11/GPX4信号通路以抑制铁死亡的相关实验 研究进行回顾与分析后发现，传统中医疗法如中药复方与中成药、中药单体及其有效成分、针灸治疗等，能通过激活Nrf2/ SLC7A11/GPX4信号通路来抑制铁死亡，为缺血性脑卒中的中医药干预提供了新的思路。

Ischemic stroke is a disease resulting from the cerebral ischemia and hypoxia caused by the blockage of brain vessels in the brain，and is characterized by the focal neurological signs. Pathologically，neuronal necrosis in the infarcted area and the neuronal degeneration or delayed death of neurons in the ischemic penumbra， contribute to the morphological basis of the disease. Ischemic stroke is regulated by multiple processes，including ferroptosis，apoptosis，and autophagy. Ferroptosis，a type of iron-dependent cell death，is closely associated with ischemic stroke. Nuclear factor erythroid 2 - related factor 2（Nrf2），a key transcription factor，plays a critical role in maintaining cellular redox balance and regulating inflammatory responses. Nrf2 promotes the expression of solute carrier family 7 member 11（SLC7A11） and glutathione peroxidase 4（GPX4），thereby activating the Nrf2 signaling pathway to counteract ferroptosis and protect cells from damage. This article reviews and analyzes recent experimental studies on traditional Chinese medicine （TCM） therapy targeting the Nrf2/SLC7A11/GPX4 pathway to suppress ferroptosis. The studies have found that TCM therapy with herbal compounds，Chinese patent medicines， single herbal components and their active ingredients，and acupuncture and moxibustion can inhibit ferroptosis by activating the Nrf2/SLC7A11/GPX4 signaling pathway， which will provide novel strategies for the TCM intervention of ischemic stroke.

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广西自然科学基金项目（编号：2023GXNSFBA026229）；广西中医药大学校级课题（编号：2022QN033）