【目的】 采用数据挖掘和知识图谱方法分析全国范围的中药配方颗粒治疗高血压的用药规律，为拓展中药配方颗粒治 疗高血压提供参考依据。【方法】 收集 2022年 1月至 2023年 3月期间全国相关中医专家治疗高血压的中药配方颗粒处方，应 用 Microsoft Excel进行药物频数、性味归经及功效类别分析；运用层次聚类方法进行聚类分析，利用 Neo4j图数据库构建各 地区治疗高血压的中药配方颗粒复方与中药关系的信息知识图谱。【结果】 共纳入中药配方颗粒 2 600首，涉及中药 370味， 使用频次居前6位的药物为茯苓、甘草、白术、陈皮、白芍、当归。所用药物的药性以温、平为主；药味多为甘、辛、苦， 药物归经以归脾、肺、肝经为主。经层次聚类后得到7个聚类。构建的各地区治疗高血压的中药配方颗粒复方与中药关系的 信息知识图谱显示，5个及以上地区均使用的中药为白芍、白术、陈皮、半夏、茯苓、天麻、柴胡、川芎、丹参、当归、甘 草、黄芪。【结论】 中药配方颗粒治疗高血压的药物以补虚药为主，性味多甘、温，归经以脾经为主，中药功效以平肝潜阳、 健脾祛湿、补益肝肾为主。

Objective To analyze the medication rules of Chinese herbal concentrated-granule for the treatment of hypertension nationwide using data mining and knowledge graph methods，thus to provide evidence for expanding its application in treating hypertension. Methods From January 2022 to March 2023，Chinese herbal concentratedgranule prescriptions for hypertension prescribed by traditional Chinese medicine experts nationwide were collected. Microsoft Excel was used to analyze the frequency， properties and flavors， meridian tropism， and efficacy categories of the medicinals. Hierarchical clustering was applied for cluster analysis，and the Neo4j graph database was utilized to construct an information knowledge graph illustrating the relationships between regions and medicinals. Results A total of 2 600 Chinese herbal concentrated-granule prescriptions were included， involving 370 medicinals. The top six frequently-used medicinals were Poria （Fuling）， Glycyrrhizae Radix et Rhizoma （Gancao），Atractylodis Macrocephalae Rhizoma （Baizhu），Citri Reticulatae Pericarpium （Chenpi），Paeoniae Radix Alba （Baishao），and Angelicae Sinensis Radix （Danggui）. The properties of the medicinals were mainly warm and mild，and their flavors were usually sweet，pungent，and bitter. The medicinals frequently have the meridian tropism of the spleen，lung，and liver meridians. Hierarchical clustering yielded seven clusters. The information knowledge graph of region-medicinals relationships revealed that medicinals used in five or more regions were Baishao，Baizhu，Chenpi，Pinelliae Rhizoma （Banxia），Fuling，Gastrodiae Rhizoma（Tianma）， Bupleuri Radix（Chaihu）， Chuanxiong Rhizoma （Chuanxiong）， Salviae Miltiorrhizae Radix et Rhizoma （Danshen）， Danggui， Gancao， and Astragali Radix（Huangqi）. Conclusion Chinese herbal concentratedgranule for hypertension usually consist of tonifying medicinals，with sweet and warm properties，and having the meridian tropism of the spleen meridian. And the medicinals composed of the prescriptions often have the actions of calming the liver and suppressing yang， strengthening the spleen and removing dampness， and nourishing the liver and kidney.

R259.441

国家重点研发计划项目（编号：2023YFC3503002）；国家自然科学基金面上项目（编号：81774451）；广东省基础与应用基础研究 项 目（编 号 ： 2022A1515220162， 2022A1515220148， 2021A1515220154）； 广 州 市 科 技 局 重 点 研 发 计 划 项 目（编 号 ： 2024B03J1293， 2023B03J0352）