【目的】 运用基于R语言的数据挖掘技术探讨李惠林教授治疗桥本甲状腺炎（HT）合并甲状腺功能减退（简称“甲减”）的 用药规律。【方法】 收集李惠林教授于 2023 年 3 月至 2024 年 3 月期间在门诊诊治的 HT 合并甲减患者的处方资料，运用 Microsoft Excel 2021建立数据库，采用R语言对中药处方进行药物频次、功效、性味、归经分析，并对处方药物进行相关性 分析、关联规则分析和聚类分析。【结果】 共纳入 57首中药处方，包含 125味中药，总用药频次为 782次。频次居前 10者分 别为炙甘草、当归、白术、黄芪、柴胡、桂枝、益母草、白芍、茯苓、五指毛桃；功效主要为补虚药；性味分析显示四气 主要以平、温为主；五味主要以甘为主；归经居前3位者分别为肝、肺、脾经。相关性分析得到5组强相关药物组合。关联 规则分析得到核心药物组合，包括炙甘草、黄芪、当归、柴胡、党参、白术、香附共7味药。对频次 ≥ 5次的药物进行聚类分 析，得到5个药物组合。【结论】 李惠林教授治疗HT合并甲减基于治病求本原则，重在健脾益气；同时注重疏肝理气，气血 同调，标本兼顾。 关键词：桥本甲状腺炎；甲状腺功能减退；R语言；健脾益气；疏肝理气；用药规律；李惠林 中图分类号：R259.81

Objective To explore the medication rules of Professor Li Huilin in treating Hashimoto’s thyroiditis （HT） complicated with hypothyroidism using data mining techniques based on the R language. Methods Prescription data of the patients with HT complicated with hypothyroidism treated by Professor Li Huilin in outpatient clinics from March 2023 to March 2024 were collected. A database was established using Microsoft Excel 2021，and R language was employed to analyze the frequency，efficacy，properties and flavors，and meridian tropism of the medicinals from Chinese herbal prescriptions. Additionally，correlation analysis，association rule analysis，and cluster analysis were performed on the medicines from Chinese herbal prescriptions. Results A total of 57 Chinese herbal prescriptions involving 125 medicinals with 782 medication frequencies were included. The top 10 frequently-used medicinals were Glycyrrhizae Radix et Rhizoma Praeparata cum Melle（Zhigancao）， Angelicae Sinensis Radix（Danggui），Atractylodis Macrocephalae Rhizoma（Baizhu），Astragali Radix（Huangqi）， Bupleuri Radix（Chaihu）， Cinnamomi Ramulus（Guizhi）， Leonuri Herba（Yimucao）， Paeoniae Radix Alba （Baishao）， Poria（Fuling）， and Fici Simplicissimae Radix（Wuzhimaotao）. Most of the medicinals had therapeutic action of tonifying deficiency. The analysis of properties and flavors showed that the majority of medicinals were mild or warm in nature， and sweet in flavor. The top three meridians having the tropism of medicinals were the liver， lung， and spleen meridians. Correlation analysis identified five strongly-correlated herbal combinations. Association rule mining revealed a core herbal combination consisting of seven medicinals of Zhigancao， Huangqi， Danggui， Chaihu， Codonopsis Radix （Dangshen）， Baizhu， and Cyperi Rhizoma （Xiangfu）. Cluster analysis of medicinals with a frequency of ≥ 5 yielded five groups of herbal combination. Conclusion For the treatment of HT complicated with hypothyroidism，Professor Li Huilin follows the principle of addressing the root cause of the disease，and focuses on strengthening the spleen and replenishing qi. Moreover， attention is given to soothing the liver and regulating qi，harmonizing qi and blood simultaneously，and treating symptoms and root cause simultaneously.

R259.81

国家自然科学基金青年项目（编号：82104759）；广东省自然科学基金青年项目（编号：2019A1515110108）；深圳市科技创新 委员会基础研究（面上项目）（编号：JCYJ20230807094504008）；第七批全国老中医药专家学术经验继承工作项目