周围神经病理性疼痛（PNP）是由周围神经系统原发性损害和功能障碍所引起的慢性疼痛，其PNP发病率较高，且随年 龄增加而上升，对患者的生活质量造成严重影响。PNP包含的常见综合征为带状疱疹后神经痛、痛性糖尿病周围神经病变、 三叉神经痛及痛性神经根病变。补阳还五汤出自清代王清任的《医林改错》，其主要功效为补气活血，祛瘀通络，是治疗气 虚血瘀之中风的代表方，现代医家已将其应用于内科多系统的病症治疗。该文对近20年有关补阳还五汤治疗PNP的临床研 究及药理学机制进行系统整理，结果表明补阳还五汤的诸药配伍，可多成分、多靶点、多途径地发挥修复神经损伤、营养 神经、促进神经再生、缓解神经病理性疼痛等作用，对多种病因所致神经损伤引发的PNP综合征均有显著疗效。该文对补 阳还五汤治疗PNP的临床研究及基础研究进行综述，可为PNP的临床治疗及拓展补阳还五汤的临床应用提供参考。

Peripheral neuropathic pain （PNP） is a chronic pain condition caused by the primary damage or the dysfunction of the peripheral nervous system. The incidence of PNP is relatively high and increases with age，and PNP has significant impact on patients’ quality of life. Common syndromes associated with PNP include postherpetic neuralgia，painful diabetic peripheral neuropathy，trigeminal neuralgia，and painful radiculopathy. Buyang Huanwu Decoction，originating from Wang Qingren’s Yi Lin Gai Cuo（Corrections on the Errors of Medical Works during） the Qing Dynasty and mainly having the actions of replenishing qi and promoting blood circulation， removing stasis and unblocking collaterals，is primarily known as a representative formula for treating stroke due to qi deficiency and blood stasis. Nowadays，modern practitioners have extended its application in treating various multi-system diseases in internal medicine. This paper systematically reviewed clinical studies and pharmacological mechanisms of Buyang Huanwu Decoction in treating PNP over the past 20 years. The results indicated that the combination of herbs in Buyang Huanwu Decoction has multi-component，multi-target，and multi-pathway effects on repairing nerve damage， nourishing nerves， promoting nerve regeneration， and alleviating neuropathic pain. Buyang Huanwu Decoction shows significant efficacy in treating PNP syndromes caused by neuropathic damage resulting from various etiological factors. This article reviewed both clinical observation and basic research on Buyang Huanwu Decoction in treating PNP，aiming to provide references for the clinical treatment of PNP and to expand the clinical applications of Buyang Huanwu Decoction.

R289.5

国家中医药管理局中西医协同“旗舰”科室建设项目（国中医药规财函[2024]86号）；广东省卫生健康适宜技术推广项目（编号： 202303192359108139）