【目的】 运用数据挖掘方法探讨王彦刚教授治疗胃食管反流病（GERD）的临证经验。【方法】 采用SPSS 23.0对王彦刚教授 于2020年1月至2022年12月期间在门诊治疗GERD的有效病案的处方资料进行中药的频次、性味及归经统计分析，并对相 关药物进行聚类分析、因子分析及关联规则分析。【结果】 共筛选得到王彦刚教授治疗 GERD 处方 294首，涉及 174味中药。 用药频次居前10者为海螵蛸、浙贝母、黄芩、黄连、清半夏、炒槟榔、茵陈、石膏、枳实、厚朴。根据聚类分析、因子分 析和关联规则分析，得到“黄芩-黄连”“陈皮-竹茹”“海螵蛸-浙贝母”“石菖蒲-郁金”“枳实-厚朴”等 16对常用药对， “黄芩、黄连、茵陈”“陈皮、竹茹、清半夏”等9组药队。对用药频次＞110次的22味药物进行因子分析，采用主成分分析 后共提取得到 6个公因子。【结论】 王彦刚教授临证辨治 GERD，以“郁热阴伤”为核心病机，以“清热养阴”为核心治法， 同时根据疾病发展过程中出现的兼夹病症，辅以利咽喉、调肝胃、养心神之法。

Objective To explore the clinical experience of Professor Wang Yan’gang in treating gastroesophageal reflux disease（GERD） using data mining methods. Methods SPSS 23.0 was used to statistically analyze the frequency，properties，flavors，and meridian tropism of Chinese herbal medicines in the prescriptions of effective GERD cases treated by Professor Wang Yan’gang in outpatient clinics from January 2020 to December 2022. Cluster analysis，factor analysis，and association rule analysis were performed on the relevant drugs. Results A total of 294 outpatient prescriptions for the treatment of GERD were collected， including 174 Chinese herbal medicines. The top 10 frequently-used drugs were Sepiae Endoconcha（Haipiaoxiao）， Fritillariae Thunbergii Bulbus（Zhebeimu）， Scutellariae Radix（Huangqin）， Coptidis Rhizoma（Huanglian）， Pinelliae Rhizoma Praeparatum Cum Alumine（Qingbanxia），Arecae Semen Tostum（Chaobinglang），Artemisiae Scopariae Herba （Yinchen），Gypsum Fibrosum（Shigao），Aurantii Fructus Immaturus（Zhishi），and Magnoliae Officinalis Cortex （Houpo）. After cluster analysis，factor analysis，and association rule analysis，16 commonly-used herb pairs， such as Huangqin-Huanglian， Citri Reticulatae Pericarpium（Chenpi）-Zhuru（Bambusae Caulis in Taenia），Haipiaoxiao-Zhebeimu，Shichangpu（Acori Tatarinowii Rhizoma）-Yujin（Curcumae Radix），and Zhishi-Houpo were identified， and 9 herb groups such as “Huangqin， Huanglian， Yinchen” and “Chenpi， Zhuru， Qingbanxia” were obtained. Factor analysis was performed on 22 drugs with a usage frequency more than 110 times，and then 6 common factors were extracted after principal component analysis. Conclusion In differentiating and treating GERD，Professor Wang Yan’gang suggests that stagnated heat injuring yin should be taken as the core pathogenesis，and therapy of clearing heat and nourishing yin should be used as the core treatment method. Additionally，auxiliary methods such as soothing the throat，regulating the liver and stomach，and nourishing the heart and spirit can be adopted according to the accompanying symptoms during the disease progression.

R256.33

北京市自然科学基金项目（编号：7232281）；河北省中医药管理局项目（编号：2021072，2021073，2022325）；河北省中西医结合 胃肠病研究重点实验室建设项目