【目的】 基于数据挖掘方法分析陈斌教授治疗慢性浅表性胃炎（CSG）的处方用药规律。【方法】 收集陈斌教授2022年10月 至 2023 年 4 月在广州中医药大学第一附属医院门诊治疗 CSG 患者且有效的病历处方数据，利用 R 语言、SPSS、IBM SPSS Modeler 软件对处方数据进行频数统计、关联规则分析及系统聚类分析，分析陈斌教授治疗 CSG 的用药组方规律。 【结果】 共纳入陈斌教授门诊处方64首，涉及中药95味，其中使用频次居前10位的中药依次为炙甘草、柴胡、法半夏、大 枣、干姜、党参、黄芩、鸡屎藤、陈皮、蒲公英；药性以温、寒、平为主，药味以甘味最多，归经以脾经、胃经、肝经常 见；药物功效以健脾益气、理气、化湿类为主。基于关联规则分析共筛选出核心药物组合为 21组，聚类分析得到 4个聚类 方。综合高频药物统计与聚类分析的结果并结合中医药理论，筛选得到治疗 CSG 的核心药物为“炙甘草，柴胡，法半夏， 大枣，干姜，党参，黄芩，鸡屎藤，陈皮，蒲公英”。【结论】 陈斌教授治疗CSG以“益气调枢”为治则，以调畅气机、健脾 和胃为治法，用药多以小柴胡汤为基础方。其从脾胃入手，强调寒温并用以治疗CSG的思路可为CSG的中医治疗提供参考。

Objective To analyze the prescription patterns of Professor Chen Bin in treating chronic superficial gastritis （CSG） with data mining methods. Methods Prescription data from effective medical records of outpatients with CSG treated by Professor Chen Bin at the First Affiliated Hospital of Guangzhou University of Chinese Medicine from October of 2022 to April of 2023 were collected. R language，SPSS，and IBM SPSS Modeler were used to perform frequency statistics，association rule analysis，and systematic cluster analysis on the prescription data， and then the medication and prescription patterns of Professor Chen Bin in treating CSG were explored. Results A total of 64 outpatient prescriptions formulated by Professor Chen Bin were included ， involving 95 Chinese herbal medicines. The top 10 frequently-used herbs were Glycyrrhizae Radix et Rhizoma Praeparata cum Melle（Zhigancao）， Bupleuri Radix（Chaihu）， Pinelliae Rhizoma Praeparatum （Fabanxia）， Jujubae Fructus（Dazao）， Zingiberis Rhizoma（Ganjiang）， Codonopsis Radix（Dangshen）， Scutellariae Radix （Huangqin）， Paederiae Herba（Jishiteng）， Citri Reticulatae Pericarpium（Chenpi）， and Taraxaci Herba （Pugongying）. Most of the herbs were warm，cold，and mild in nature，and were sweet in flavor. And the herbs mainly had the meridian tropism of spleen，stomach，and liver meridians，and had the primary therapeutic effects of strengthening the spleen and replenishing qi，regulating qi，and resolving dampness. Based on the results of association rule analysis，a total of 21 core herb combinations were screened out，and cluster analysis yielded 4 clustered prescriptions. Combining the results of high-frequency herb statistics and cluster analysis and based on the traditional Chinese medicine theory，the core herbs for treating CSG was identified as Zhigancao，Chaihu， Fabanxia， Dazao， Ganjiang， Dangshen， Huangqin， Jishiteng， Chenpi， and Pugongying. Conclusion In treating CSG，Professor Chen Bin adheres to the treatment principle of replenishing qi and regulating the pivot， and the therapeutic methods of regulating qi movement，strengthening the spleen and harmonizing the stomach are applied with Xiaochaihu Decoction as the fundamental prescriptions. His view of treatment by focusing on the spleen and stomach，emphasizing the combination of herbs with cold and warm properties and based on syndrome differentiation will provide a reference for the clinical application of traditional Chinese medicine in treating CSG.

R256.33

国家自然科学基金项目（编号：82074197）