【目的】 观察岭南火针疗法联合常规西医治疗轻中度子宫脱垂的临床疗效。【方法】 选取 2023年 1月至 2024年 1月东莞 市虎门中医院门诊与病房收治的96例明确诊断为轻中度子宫脱垂患者为研究对象。按随机数字表将患者随机分为观察组和 对照组，每组各48例。2组患者均给予健康宣教，对照组给予常规西医治疗，观察组在对照组治疗的基础上，给予岭南火针 治疗。治疗12次为1个疗程，治疗1个疗程。治疗后，评价2组临床疗效。观察2组患者治疗前后中医证候积分和盆底肌力 的变化情况，以及超声影像特征的情况。比较 2组患者治疗前后血清骨桥蛋白（OPN）、结缔组织生长因子（CTGF）、基质金 属蛋白酶-9/金属蛋白酶抑制因子 1（MMP-9/TIMP-1）水平的变化情况。并评价 2组的安全性及不良反应的发生情况。【结果】 （1）观察组总有效率为97.92%（47/48），对照组为77.08%（37/48）。观察组疗效优于对照组，差异有统计学意义（P＜0.05）。（2）治 疗后，2组患者的各项中医证候积分及总积分均明显改善（P＜0.05），且观察组在改善各项中医证候积分及总积分方面明显 优于对照组，差异有统计学意义（P＜0.05）。（3）治疗后，2组患者盆底肌力、超声影像特征均明显改善（P＜0.05），且观察组 在改善盆底肌力、超声影像特征方面明显优于对照组，差异均有统计学意义（P＜0.05）。（4）治疗后，2 组患者的血清 OPN、 CTGF、MMP-9/TIMP-1水平均明显改善（P＜0.05），且观察组在改善血清OPN、CTGF、MMP-9/TIMP-1水平方面明显优于对 照组，差异均有统计学意义（P＜0.05）。（5）2组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。【结论】 岭南火针疗 法联合常规西医治疗轻中度子宫脱垂，可明显改善患者症状及盆底肌力，疗效显著，安全性高，其作用机制可能与调节 OPN、CTGF及MMP-9/TIMP-1水平有关。

Objective To observe the clinical efficacy of Lingnan fire needle therapy combined with conventional western medicine in the treatment of mild to moderate uterine prolapse. Methods A total of 96 patients diagnosed with mild to moderate uterine prolapse in the outpatient and inpatient departments of Dongguan Humen Traditional Chinese Medicine Hospital from January 2023 to January 2024 were selected as the study subjects. The patients were randomly divided into an observation group and a control group using a random number table，with 48 cases in each group. Both groups received health education， and the control group received conventional western medicine treatment. The observation group received Lingnan fire needle therapy in addition to the control group’s treatment. The treatment course consisted of 12 sessions，with one course completed. After treatment，the clinical efficacy of the two groups was evaluated. Changes in TCM syndrome scores，pelvic floor muscle strength，and ultrasound imaging characteristics were observed before and after treatment. The serum levels of osteopontin（OPN）， connective tissue growth factor（CTGF）， and matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 （MMP-9/TIMP-1） were compared before and after treatment. The safety and incidence of adverse reactions in the two groups were evaluated. Results （1） The total effective rate in the observation group was 97.92% （47/48）， while it was 77.08% （37/48） in the control group. The efficacy of the observation group was superior to that of the control group， with a statistically significant difference （P＜0.05）.（2） After treatment， the TCM syndrome scores and total scores in both groups significantly improved （P＜0.05）， and the observation group showed significantly better improvement in these scores compared to the control group， with a statistically significant difference （P＜0.05）.（3） After treatment，the pelvic floor muscle strength and ultrasound imaging characteristics in both groups significantly improved（P＜0.05）， and the observation group showed significantly better improvement in these aspects compared to the control group，with a statistically significant difference （P＜0.05）. （4） After treatment， the serum levels of OPN， CTGF， and MMP-9/TIMP-1 in both groups significantly improved （P＜0.05），and the observation group showed significantly better improvement in these levels compared to the control group，with a statistically significant difference （P＜0.05）.（5） There was no statistically significant difference in the incidence of adverse reactions between the two groups （P＞0.05）. Conclusion Lingnan fire needle therapy combined with conventional western medicine can significantly improve symptoms and pelvic floor muscle strength in patients with mild to moderate uterine prolapse，with notable efficacy and high safety. The mechanism may be related to the regulation of OPN，CTGF，and MMP-9/TIMP-1 levels.

R246.9

国家自然科学基金面上资助项目（编号：81574061）；广东省中医药科研资助项目（编号：20211129）；东莞市社会发展科技资助 项目（编号：20211800902832）