【目的】 探究精苓口服液（由何首乌、黄精、柏子仁、莲子、女贞子、茯苓、百合等中药组成）辅助治疗对全面性发育 迟缓（GDD）患儿认知、运动和社交能力的影响。【方法】 选取2021年7月至2023年11月于河北省儿童医院神经康复科就诊的120 例GDD患儿作为研究对象，采用随机数字表法将患儿随机分为对照组和试验组，每组各60例。对照组患儿接受常规综合康 复训练治疗，试验组患儿在对照组的基础上给予精苓口服液辅助治疗，疗程为12周。观察2组患儿治疗前后Gesell发育量表 （GDS）评分、Peabody运动发育量表（PDMS）评分、运动功能评分和语言能力评分的变化情况，以评价2组患儿的认知、运动 和社交能力。【结果】（1）治疗后，2组患儿GDS的适应性、精细运动发育商、语言发育商和个人-社交发育商等各维度评分均 较治疗前明显升高（P＜0.01），且试验组对 GDS 各维度评分的升高作用均明显优于对照组（P＜0.01）。（2）治疗后，2 组患儿 PDMS 的精细运动发育商、视觉运动整合标准分和抓握标准分等各维度评分均较治疗前明显升高（P＜0.01），且试验组对 PDMS各维度评分的升高作用均明显优于对照组（P＜0.01）。（3）治疗后，2组患儿的精细运动（FMQ）、粗大运动（GMQ）和总运 动（TMQ）等运动功能评分均较治疗前明显升高（P＜0.01），且试验组对各项运动功能评分的升高作用均明显优于对照组（P＜ 0.01）。（4）治疗后，2组患儿的语言能力评分均较治疗前明显升高（P＜0.01），且试验组对语言能力评分的升高作用明显优于 对照组（P＜0.01）。【结论】 在常规综合康复训练治疗基础上联合精苓口服液辅助治疗，可有效提升GDD患儿的认知、运动和 社交能力水平。

Objective To explore the effects of Jingling Oral Liquid（mainly composed of Polygoni Multiflori Radix， Polygonati Rhizoma，Platycladi Semen，Nelumbinis Semen，Ligustri Lucidi Fructus，Poria，and Lilii Bulbus） as an adjunctive therapy on cognitive， motor， and social abilities in children with global developmental delay （GDD）. Methods A total of 120 children with GDD who visited the Department of Neurological Rehabilitation at Hebei Children’s Hospital from July 2021 to November 2023 were selected as the study subjects. The children were randomly divided into a control group and a trial group using a random number table，with 60 children in each group. The control group received conventional comprehensive rehabilitation training， while the trial group received Jingling Oral Liquid as an adjunctive therapy in addition to the control group’s treatment. The treatment course lasted 12 weeks. Before and after treatment，the changes in Gesell Developmental Scale （GDS） scores， Peabody Developmental Motor Scales （PDMS） scores，motor function scores，and language ability scores in both groups were observed to evaluate the cognitive， motor， and social abilities of the children. Results （1） After treatment，the scores of all dimensions of the GDS，including adaption，developmental quotient of fine motor，language developmental quotient， and personal-social developmental quotient， were significantly increased in both groups compared to those before treatment （P＜0.01），and the improvement of GDS scores in the trial group was significantly superior to that in the control group （P＜0.01）.（2） After treatment，the scores of all dimensions of the PDMS，including fine developmental quotient score，standardized score of visual-motor integration，and standardized score of grasping，were significantly increased in both groups compared to those before treatment（P＜ 0.01），and the improvement of PDMS scores in the trial group was significantly superior to that in the control group （P＜0.01）.（3） After treatment， the scores of motor function indicators of fine motor quotient （FMQ）， gross motor quotient（GMQ），and total motor quotient （TMQ） were significantly increased in both groups compared to those before treatment（P＜0.01），and the improvement of motor function scores in the trial group was significantly superior to that in the control group（P＜0.01）.（4） After treatment，the language ability scores were significantly increased in both groups compared to those before treatment （P＜0.01），and the improvement of language ability scores in the trial group was significantly superior to that in the control group （P＜0.01）. Conclusion The combination of Jingling Oral Liquid with conventional comprehensive rehabilitation training can effectively improve the cognitive，motor，and social abilities of children with GDD.

R272.6

国家自然科学基金资助项目（编号：61976008）；河北省医学科学研究课题资助项目（编号：20211006）