为了进一步推动特应性皮炎（AD）中西医结合治疗的规范化，由岐黄学者陈达灿教授团队牵头制订了《特应性皮炎中 西医结合临床实践指南》（简称《指南》）。该文详述了《指南》编制过程，并分析《指南》的特点及编制中遇到的难点与对 策。该 《指南》 的制订遵循国际临床试验指南的方法学，由来自中医、西医、中西医结合、方法学等不同学科的专家成立 专家组和工作组，在系统文献调研的基础上，充分总结临床一线专家经验，经多次会议讨论共同编制形成初稿。制订该 《指南》的过程中，遇到了不少的问题，该项目组在分析这些问题后，找到了相应的对策，形成了该《指南》的特色：整合 传统中医与西医疗法，评价中西医结合证据，解决AD的中西医诊疗缺乏规范的问题；充分结合证据与临床实践经验，解决 AD的中医整体证据不足和级别偏低的问题；充分考量中西医的各自优势，制订AD的疾病管理目标和策略，接轨国际治疗 与管理理念；有效融合中西医疗法，制订个体化中医与西医结合策略，满足AD不同特点的患者临床需求。该《指南》的制 订过程及面临的问题及对策分析，可为后续其他中西医结合临床指南的制订提供借鉴与思考。

In order to further promote the standardization of the integrated traditional Chinese and western medicine treatment of atopic dermatitis （AD），the team of Professor Chen Dacan，who is honored as the Qihuang Scholar， developed the Clinical Practice Guidelines for Integrated Traditional Chinese and Western Medicine in Atopic Dermatitis（hereinafter referred to as Guidelines for AD）. This paper detailed the process of development of Guidelines for AD， and analyzed the characteristics of Guidelines for AD， as well as the difficulties and countermeasures encountered during such a time. The development of Guidelines for AD follows the methodology of international guidelines for clinical trial. Experts specializing in various disciplines，such as traditional Chinese medicine，western medicine，integrated traditional Chinese and western medicine，and methodology，composed an expert group and a working group. On the basis of systematic literature research， the clinic experiences of frontline experts were well-summarized，and the draft of Guidelines for AD was formed after several meetings and discussions. In the process of developing Guidelines for AD，quite a number of problems were encountered，and the project team found the corresponding countermeasures after analyzing these problems. The countermeasures became the characteristics of Guidelines for AD： the integration of traditional Chinese medicine therapies and western medicine therapies， and the evaluation of the evidence of integrated traditional Chinese and western medicine solved the problem of traditional Chinese and western medicine diagnosis and treatment of AD lacking standardization； the adequately combination of the evidence with the experience of clinical practice solved the problems of the low overall level and the insufficiency of traditional Chinese medicine evidence for AD； the establishment of management goals and strategies for AD after taking the advantages of both traditional Chinese medicine and western medicine into account was in line with the international treatment and management concepts； the formulation of individualized traditional Chinese and western medicine therapy based on the integration of traditional Chinese medicine therapy and western medicine therapy met the clinical needs of patients with different characteristics of AD. The development process of Guidelines for AD and the analysis of problems and countermeasures during such a time will provide reference and reflection for the subsequent establishment of clinical guidelines for the integrated traditional Chinese and western medicine in other diseases.

R275.9

国家自然科学基金面上项目（编号：82004364）；国家中医药管理局中西医结合与少数民族医药司政府采购服务项目（编号：2023376）； 陈达灿全国名老中医药专家传承工作室建设项目（国中医药人教函 〔2022〕 75号）；广州市科技局资助项目（编号：2023B03J0562）