【目的】 基于数据挖掘技术探究针灸治疗阿尔茨海默病认知障碍的穴位选择规律，为临床实践提供治疗参考。【方法】 通过计算机搜索中国期刊全文数据库（CNKI）、万方学术期刊全文数据库（Wanfang）、维普中文科技期刊数据库（VIP）、中国 生物医学文献数据库（CBM）、美国生物医学信息检索系统（PubMed）、核心合集数据库（Web of Science）和荷兰医学文献数据 库（Embase）等各大数据库，选取自数据库建库以来至2024年5月1日有关针灸治疗阿尔茨海默病认知障碍的临床研究文献， 使用Microsoft Excel 2019建立针灸处方数据库，使用SPSS Statistics 24.0及SPSS Modeler 18.0进行关联分析及聚类分析，探究 针灸治疗阿尔茨海默病认知障碍的选穴规律。【结果】 共纳入文献48篇，使用腧穴73个，腧穴总使用频次327次。腧穴分析 结果显示，选穴以督脉和头项部穴位为主，使用频次较高的前3位腧穴为：百会、四神聪、神庭。关联规则分析结果表明， 腧穴中置信度最高的关联群是百会-大椎、百会-神庭、百会-四神聪、百会-内关、百会-肾俞；高频聚类分析结果显示出 4个聚类群：三阴交-本神、神门-印堂-太冲-丰隆-肾俞-大椎、太溪-内关-足三里-关元、风池-神庭。【结论】 针灸治疗阿 尔茨海病认知障碍取穴方面多以督脉和头项部取穴为主；可将“百会-四神聪-神庭-风池”作为临床治疗的核心取穴，临床 中可结合辨证论治随证加减应用。

Objective To explore the acupoint selection patterns in acupuncture treatment for cognitive impairment in Alzheimer’s disease based on data mining technology，and to provide references for clinical practice. Methods Computer searches were conducted in major databases including the China National Knowledge Infrastructure （CNKI）， Wanfang Academic Journal Full-Text Database （Wanfang）， VIP China Science and Technology Journal Database （VIP），China Biology Medicine （CBM），PubMed，Web of Science，and Embase. Clinical research literature on acupuncture treatment for cognitive impairment in Alzheimer’s disease from the inception of the databases to May 1，2024 was selected. Microsoft Excel 2019 was used to establish a database of acupuncture prescriptions， and SPSS Statistics 24.0 and SPSS Modeler 18.0 were used for association analysis and cluster analysis to explore the acupoint selection patterns in acupuncture treatment for cognitive impairment in Alzheimer’s disease. Results A total of 48 articles were included，involving 73 acupoints with a total frequency of 327 uses. The analysis of acupoints showed that the selection of acupoints mainly focused on the governor vessel and head/ neck regions. The top three most frequently used acupoints were Baihui（GV20），Sishencong（EX-HN1），and Shenting（GV24）. The association rule analysis indicated that the acupoint groups with the highest confidence were Baihui-Dazhui（GV14），Baihui-Shenting，Baihui-Sishencong，Baihui-Neiguan（PC6），and Baihui-Shenshu （BL23）. The high-frequency cluster analysis revealed four clusters：Sanyinjiao（SP6）-Benshen（GB13），Shenmen （HT7）-Yintang（EX-HN3）-Taichong（LR3）-Fenglong（ST40）-Shenshu-Dazhui（GV14），Taixi （KI3）-NeiguanZusanli（ST36）-Guanyuan（CV4）， and Fengchi（GB20）-Shenting. Conclusion In acupuncture treatment for cognitive impairment in Alzheimer’s disease，acupoint selection mainly focuses on the governor vessel and head/ neck regions. The combination of “Baihui-Sishencong-Shenting-Fengchi” can be used as the core acupoint selection in clinical treatment，and it can be adjusted based on syndrome differentiation and treatment in clinical practice.

R246.9

陕西省自然科学基础研究计划基金资助项目（编号：2023-JC-YB-735）