【目的】 观察中医序贯疗法治疗深圳市寻常型银屑病的临床疗效，探讨深圳地域寻常型银屑病的辨治规律。【方法】 回 顾性分析 2019年 1月至 2024年 2月广州中医药大学附属宝安中医院（深圳市宝安区中医院）收治的 70例寻常型银屑病患者， 按照治疗方案不同分为观察组39例和对照组31例。对照组全程仅给予卡泊三醇软膏外涂治疗，观察组在对照组的基础上按 照疾病病程阶段使用中医序贯疗法治疗，急性期给予水牛角黄连汤加减内服，缓解期给予四君子水牛角汤加减内服，2组疗 程均为3个月。观察2组患者治疗前后银屑病皮损面积和严重程度指数（PASI）评分、皮肤病生活质量量表（DLQI）评分和中医 证候积分的变化情况，并评价2组患者的临床疗效及用药安全性。【结果】（1）临床疗效方面，治疗3个月后，观察组的总有 效率为 89.74%（35/39），对照组为 74.19%（23/31），组间比较（χ2检验），观察组的疗效明显优于对照组（P＜0.05）。（2）皮损严 重程度方面，治疗后，2 组患者的 PASI 评分均较治疗前明显降低（P＜0.05），且观察组的降低幅度明显优于对照组（P＜ 0.05）。（3）对生活质量的影响方面，治疗后，2组患者的DLQI评分均较治疗前明显降低（P＜0.05），且观察组的降低幅度明显 优于对照组（P＜0.05）。（4）中医证候积分方面，治疗后，2组患者的红斑、瘙痒、心烦、口干等各项中医证候积分均较治疗 前明显降低（P＜0.05），且观察组的降低幅度均明显优于对照组（P＜0.05）。（5）安全性方面，治疗期间，2组患者均未出现明 显的不良反应，具有较高的安全性。【结论】 在西医常规治疗基础上使用中医序贯疗法治疗深圳市寻常型银屑病患者临床疗 效确切，可使患者病情得到有效控制，症状得到明显缓解，生活质量得到显著提高。

Objective To observe the clinical efficacy of traditional Chinese medicine （TCM） sequential therapy in treating patients with psoriasis vulgaris in Shenzhen，and to explore the syndrome differentiation and treatment for the patients with psoriasis vulgaris in Shenzhen region. Methods From January 2019 to February 2024，70 cases of psoriasis vulgaris admitted to Shenzhen Bao’an Traditional Chinese Medicine Hospital Affiliated to Guangzhou University of Chinese Medicine（Shenzhen Bao’an Traditional Chinese Medicine Hospital Group） were retrospectively analyzed. The patients were divided into the observation group（39 cases） and the control group（31 cases） according to the treatment plans. In the control group，only topical application of Calcipotriol Ointment was given throughout the treatment，while in the observation group the patients were treated with TCM sequential therapy according to the illness stage on the basis of treatment for the control group， i. e.， internal administration of modified Shuiniujiao Huanglian Decoction was given in the acute stage and modified Sijunzi Shuiniujiao Decoction was given in the remission stage. Both groups were treated for 3 months. Before and after the treatment， the changes of Psoriasis Area and Severity Index （PASI） scores，Dermatology Life Quality Index （DLQI） scores and TCM syndrome scores in the two groups were observed. After treatment，the clinical efficacy and drug safety of the two groups were evaluated. Results （1） After 3 months of treatment，the total effective rate of the observation group was 89.74%（35/39），and that of the control group was 74.19%（23/31）. The intergroup comparison （tested by chi-square test） showed that the efficacy of the observation group was significantly superior to that of the control group （P＜0.05）.（2） After treatment，the PASI scores for evaluating the severity of skin lesions in the two groups were significantly decreased compared with those before treatment （P＜0.05），and the decrease in the observation group was significantly superior to that in the control group （P＜0.05）.（3） After treatment，the DLQI scores for evaluating the quality of life in the two groups were significantly decreased compared with those before treatment （P＜0.05），and the decrease in the observation group was significantly superior to that in the control group （P＜ 0.05）.（4） After treatment，the scores of TCM syndromes such as erythema，itching，vexation and dry mouth in the two groups were significantly decreased compared with those before treatment （P＜0.05），and the decrease in the observation group was significantly superior to that in the control group （P＜0.05）.（5） During the treatment period，no obvious adverse reactions occurred in the two groups of patients，with high safety. Conclusion On the basis of conventional western medicine treatment， application of TCM sequential therapy exerts certain clinical efficacy in treating patients with psoriasis vulgaris in Shenzhen region，and the combined therapy is effective on controlling the patients’ illness conditions，significantly alleviating the symptoms and improving the quality of life of the patients.

R275.9

广东省中医药局中医药科研项目（编号：20231293）；深圳市“医疗卫生三名工程”项目（编号：SZZYSM202106008）；深圳市 宝安区医疗卫生基础研究项目（编号：2020JD510）