【目的】 探讨伤科黄水治疗火热伤津型小面积深Ⅱ度烧伤创面的临床疗效。【方法】 选取2024年1月～2024年7月在佛山 市中医院就诊并确诊为火热伤津型小面积深Ⅱ度烧伤的60例患者为研究对象，采用随机数字表法将患者随机分为试验组和 对照组，每组各30例。试验组给予伤科黄水纱外敷治疗，对照组给予磺胺嘧啶银乳膏外涂治疗，治疗21 d，并随访7 d。观 察2组患者治疗前后创面疼痛视觉模拟量表（VAS）评分及血清C反应蛋白（CRP）、白细胞介素6（IL-6）、肿瘤坏死因子α（TNF- α）水平的变化情况，比较2组患者的创面愈合率、创面愈合时间、创面细菌感染情况及不良反应发生情况。【结果】（1）病例 脱落情况方面，治疗过程中，试验组无脱落病例，对照组脱落 1 例，最终共 59 例患者纳入统计分析，其中试验组 30 例， 对照组 29 例。（2）创面愈合率方面，治疗第14、21天，2组患者的创面愈合率均较治疗第7天明显提高（P＜0.05），且试验组 在治疗第 14、21 天的创面愈合率均明显优于对照组（P＜0.05）。（3）创面完全愈合时间方面，试验组的创面完全愈合时间为 （22.07 ± 2.30）d，较对照组的（27.07 ± 4.10）d明显缩短（P＜0.05）。（4）创面疼痛评分方面，治疗第7、14、21天后，2组患者的 创面疼痛 VAS 评分均较治疗前降低（P＜0.05），且试验组在治疗第 7、14 天的创面疼痛 VAS 评分均明显低于对照组（P＜ 0.05）。（5）血清炎症因子方面，治疗第7天，2组患者的血清CRP、IL-6、TNF-α水平均较治疗前降低（P＜0.05），且试验组在 治疗第7天的血清CRP、IL-6、TNF-α水平均明显低于对照组（P＜0.05）。（6）创面细菌感染情况方面，治疗第7天，试验组患 者的创面细菌培养阳性率为6.67%（2/30），明显低于对照组的27.59%（8/29），差异有统计学意义（P＜0.05）。（7）安全性方面， 试验期间，2组患者均无严重不良事件和不良反应发生。【结论】 伤科黄水可促进烧伤创面愈合，缩短创面愈合时间，降低创 面感染率，降低血清炎症因子水平，且不良反应少，安全性高。

Objective To investigate the clinical efficacy of Shangke Huangshui medicated gauze in the treatment of small-area deep second-degree burn wounds with fire-heat injuring fluid type. Methods Sixty patients who were diagnosed as small-area deep second-degree burn wounds of fire-heat injuring fluid type in Foshan Hospital of Traditional Chinese Medicine from January 2024 to July 2024，were selected as the research objects. The patients were randomly divided into trial group and control group by random number table method，with 30 cases in each group. The trial group was treated with external application of Shangke Huangshui medicated gauze， and the control group was treated with external application of Silver Sulfadiazine Cream. The treatment lasted for 21 days， and then the patients were followed up for 7 days. The changes of Visual Analogue Scale （VAS） score of wound pain，and serum levels of C-reactive protein （CRP），interleukin-6（IL-6） and tumor necrosis factor-α（TNF-α） in the two groups were observed before and after treatment. The wound healing rate，wound healing time，bacterial infection of the wound， and adverse reactions were compared between the two groups. Results （1） During the treatment，there was no fell-off case in the trial group while there was one patient falling off from the control group. Eventually，a total of 59 patients were included in the statistical analysis，including 30 in the trial group and 29 in the control group.（2） On day 14 and 21 of treatment，the wound healing rates of the two groups were significantly higher than those on day 7 of treatment（P＜0.05），and wound healing rates in the trial group on the day 14 and 21 of treatment were significantly superior to those of the control group （P＜0.05）.（3）The time for the complete healing of wound in the trial group was （22.07 ± 2.30） days，which was significantly shorter than that of the control group （[ 27.07 ± 4.10） days]，and the difference was statistically significant （P＜0.05）.（4）After 7，14 and 21 days of treatment，the VAS scores of wound pain in the two groups were lowered compared with those before treatment（P＜0.05），and the VAS scores in the trial group were significantly lower than those in the control group （P＜0.05）.（5） On day 7 of treatment，the levels of serum CRP，IL-6 and TNF-α in the two groups were lowered compared with those before treatment （P＜0.05），and the levels in the trial group were significantly lower than those in the control group （P＜0.05）.（6） On day 7 of treatment，the positive rate of bacterial culture for wound discharge in the trial group was 6.67%（2/30），which was significantly lower than 27.59%（8/29） in the control group， and the difference was statistically significant （P＜0.05）. （7）There were no serious adverse events or adverse reactions occurring in the two groups during the trial. Conclusion Shangke Huangshui medicated gauze can accelerate the healing of burn wounds，shorten the wound healing time，reduce the wound infection rate and the level of serum inflammatory factors，and has fewer adverse reactions with high safety.

R269.44

广东省重点领域研发计划项目（编号：2020B1111590001）；佛山市“十四五”医学培育专科项目（编号：FSPY145205）