自身免疫性疾病是由机体免疫失衡、免疫细胞异常活化、炎症因子以及免疫复合物大量产生，从而导致多脏器、多 系统受损的一类疾病，临床易反复发作。中医湿邪致病与机体免疫功能紊乱存在相关性。该文结合既往研究阐释中医湿邪 与自身免疫性疾病复发相关性的理论依据，探析二者在临床表现、发病特点等方面的相似性，分析湿邪与自身免疫性疾病 可能存在的生物学机制联系；并探讨自身免疫性疾病如银屑病、类风湿关节炎、溃疡性结肠炎、肾病综合征的复发与中医 湿邪的相关性。认为湿邪是自身免疫性疾病复发的重要致病因素，与自身免疫性疾病复发具有相关性；从中医湿邪治疗自 身免疫性疾病可采用健脾益气祛湿的疗法，以缓解患者的临床症状，降低疾病复发率。

Autoimmune disease is a kind of disease characterized by immune imbalance，abnormal activation of immune cells，massive production of inflammatory factors and immune complexes，which leads to the damage of multiple organs and systems. Autoimmune disease is easy to recur in clinical practice. The previous studies showed that there is a correlation between dampness syndrome in traditional Chinese medicine(TCM) and immune dysfunction. This paper explains the theoretical basis for the correlation between dampness syndrome of TCM and the recurrence of autoimmune diseases，and the similarities between the two in macro appearance，pathogenesis characteristics，etc.，analyzes the possible correlation about biological mechanism between dampness syndrome and autoimmune diseases，and discussed the correlation between pathogenic dampness of TCM and the recurrence of autoimmune diseases such as psoriasis，rheumatoid arthritis，ulcerative colitis，and nephrotic syndrome. It is pointed out that pathogenic dampness of TCM is an important pathogenic factor for the recurrence of autoimmune diseases，and is closely related to the recurrence of autoimmune diseases. Autoimmune diseases can be treated from the perspective of pathogenic dampness in TCM， and therapy of invigorating spleen， replenishing qi and removing dampness is frequently adopted，which is beneficial to alleviating the clinical symptoms of patients and reducing the recurrence of autoimmune disease.

R259.932

国家自然科学基金项目（编号：U23A6012，U20A20397）；国家中医药管理局中医药创新团队及人才支持计划项目（编号：ZYY? CXTD-C-202204）；省部共建中医湿证国家重点实验室重点项目（编号：SZ2021ZZ45，SZ2021ZZ29）；广东省科技计划项目（编号： 2020B1111100006，2020B1212030006）；广州市科技计划项目（编号：202201020332，202201020317）；广东省中医药科学院研究专项（编号： YN2021DB03，ZY2022KY10，BJ2022KY05）；中华中医药学会青年人才托举工程项目（编号：2021-QNRC2-B07）