魏爱生教授基于“浊毒”理论并结合多年临证实践，提出脾气虚致浊毒内生为以肥胖/代谢紊乱为特点的 2型糖尿病 （T2DM）的关键病机，中后期因浊毒久蕴可致三焦不畅、脏腑损伤，据此提出早期截毒的观点，立“益气分消化浊”法，拟 定三黄茵陈五苓散为主方，该方是于经方茵陈五苓散中加入黄芪、黄连和麻黄而成，可益气以扶正，分消三焦而化痰湿郁 热，使脾气健，三焦畅，浊毒化，从而提高T2DM的疗效。

Based on the viewpoints of turbidity and toxin and years of clinical experience，professor Wei Aisheng proposed that spleen qi deficiency leading to internal retention of turbidity and toxin contributes to the key pathogenesis of patients with type 2 diabetes mellitus（T2DM）characterized by obesity or metabolic disorders. For T2DM patients with obesity or metabolic disorders in the middle and end stages，long-term retention of turbidity and toxin leads to unsmooth qi movement of triple energizer and damage of viscera. Therefore，Professor Wei put forward the viewpoint of cutting off the toxin in the early stage，and established the therapy of replenishing qi， respectively expelling pathogens and eliminating turbidity from triple energizer. Professor Wei formulated Sanhuang Yinchen Wuling San as the primary prescription for T2DM. The prescription is derived from the classical formula Yinchen Wuling San with the herbs of Astragali Radix，Coptidis Rhizoma and Ephedrae Herba added，having the actions of replenishing qi and supporting healthy qi， respectively expelling pathogens from triple-energizer to resolve phlegm-damp and stagnated heat. The application of Sanhuang Yinchen Wuling San for T2DM can invigorate spleen qi，smooth qi movement of triple energizer，and eliminate turbidity and toxin，and enhance the efficacy for T2DM.

R255.4

广东省中医药管理局省级名中医传承工作室建设项目（粤中医办涵[2023]10 号）；广东省医学科研项目（编号：B2021340）； 魏爱生佛山市名中医传承工作室建设项目（佛卫函[2022]92号）