【目的】 观察加味当归饮子联合揿针疗法治疗血虚风燥型慢性自发性荨麻疹的临床疗效。【方法】 选取 2023 年 7 月至 2024年2月广州中医药大学第七临床医学院皮肤科病房及门诊收治的68例明确诊断为血虚风燥型慢性自发性荨麻疹的患者 作为研究对象。按照随机数字表法将患者随机分为观察组和对照组，每组各34例。对照组给予盐酸西替利嗪片治疗，观察 组在对照组治疗的基础上，给予加味当归饮子联合揿针治疗，共治疗 4周。治疗 1个月后，评价 2组临床疗效，观察 2组患 者治疗前后荨麻疹活动度评分（UAS）与皮肤病生活质量指数（DLOI）评分的变化情况，以及中医证候积分的情况。比较2组患 者治疗前后血清总免疫球蛋白E（总IgE）含量的变化情况。并评价2组的安全性及复发情况。【结果】（1）观察组的总有效率为 91.18%（31/34），对照组为 70.59%（24/34）；组间比较（Ridit检验），观察组疗效优于对照组，差异有统计学意义（P < 0.05）。 （2）治疗 2、3、4周后，2组患者的UAS评分均明显改善（P < 0.05），且观察组在改善UAS评分方面均明显优于对照组，差异 有统计学意义（P < 0.01）。（3）治疗后，2组患者的DLQI评分与中医证候积分均明显改善（P < 0.05），且观察组在改善DLQI评 分与中医证候积分方面均明显优于对照组，差异均有统计学意义（P < 0.01）。（4）治疗后，2组患者的总 IgE 水平均明显改善 （P < 0.05），且观察组在改善总 IgE水平方面明显优于对照组，差异有统计学意义（P < 0.01）。（5）2组患者的不良反应发生率 比较，差异无统计学意义（P > 0.05）。（6）治疗后随访3个月，观察组复发率为5.88%（2/34），对照组为23.53%（8/34），观察组 复发率明显低于对照组，差异有统计学意义（P < 0.05）。【结论】 加味当归饮子联合揿针疗法治疗血虚风燥型慢性自发性荨麻 疹，能明显缓解患者的临床症状，提高患者的生活质量，降低复发率，疗效显著。

Objective To observe the clinical efficacy of modified Danggui Yinzi combined with thumb-tack needling for subcutaneous embedding in the treatment of chronic spontaneous urticaria（CSU）of wind dryness due to blood deficiency type. Methods A total of 68 cases of patients admitted to the dermatology wards and outpatient clinics of The Seventh Clinical School of Guangzhou University of Chinese Medicine with a definitive diagnosis of CSU of wind dryness due to blood deficiency type were selected as the study subjects from July 2023 to February 2024. The patients were randomly divided into the observation group and the control group according to the random number table method，with 34 cases in each group. The control group was treated with Cetirizine Dihydrochloride Tablets，and the observation group was treated with modified Danggui Yinzi combined with thumb-tack needling for subcutaneous embedding based on the treatment of the control group， the course of treatment covered four weeks. After one month of treatment，the clinical efficacy of the two groups was evaluated，and the changes in Urticaria Activity Score （UAS） and Dermatology Life Quality Index （DLQI） scores and traditional Chinese medicine（TCM）syndrome scores before and after treatment were observed in the two groups. The changes of serum total immunoglobulin E（total IgE）levels before and after treatment in the two groups were compared. The safety and recurrence cases of the two groups were evaluated. Results（1）The total effective rate was 91.18%（31/34）in the observation group and 70.59%（24/34）in the control group. The efficacy of the observation group was superior to that of the control group，the difference being statistically significant（P < 0.05）.（2）After two，three，and four weeks of treatment， the UAS scores of the patients in the two groups were improved significantly（P < 0.05），and the improvement in the observation group was significantly superior to that in the control group，the difference being statistically significant（P < 0.01）.（3）After treatment， the DLQI scores and TCM syndrome scores of the patients in the two groups were improved significantly（P < 0.05）， and the improvement in the observation group was significantly superior to that in the control group， the difference being statistically significant（P < 0.01）.（4）After treatment， the total IgE levels of patients in the two groups were improved significantly（P < 0.05），and the improvement in the observation group was significantly superior to that in the control group，the difference being statistically significant（P < 0.01）.（5）The comparison of the incidence of adverse reactions between the two groups showed that the difference being not statistically significant（P > 0.05）. （6）In the follow-up after the completion of treatment，the recurrence rate was 5.88%（2/34）in the observation group and 23.53%（8/34）in the control group，and the recurrence rate of the observation group was significantly lower than that of the control group，the difference being statistically significant（P < 0.05）. Conclusion Modified Danggui Yinzi combined with thumb-tack needling for subcutaneous embedding in the treatment of CSU of wind dryness due to blood deficiency type can significantly alleviate the clinical symptoms of the patients，improve their quality of life，and reduce the recurrence rate.

R246.9

深圳市政府“医疗卫生三名工程”广东省中医院禤国维国医大师皮肤研究团队资助项目（编号：SZZYSM202106008）