【目的】 观察调任通督电针治疗中晚期宫颈癌肿瘤相关性疲乏（CRF）的临床疗效及对炎症因子的影响。【方法】 选取2021年 8月至2023年8月沧州市中心医院病房及门诊收治的122例明确诊断为中晚期宫颈癌CRF患者为研究对象。按随机数字表将 患者随机分为对照组和观察组，每组各61例。2组患者自化疗当天开始均给予护胃、止呕等常规对症治疗。对照组给予地塞 米松片治疗，观察组在对照组治疗的基础上，给予调任通督电针治疗，共治疗21 d。治疗3周后，评价2组临床疗效，观察 2组患者治疗前后中医证候积分和Piper疲乏量表（PFS）评分的变化情况，以及Karnofsky功能状态（KPS）评分和癌症患者生命 质量测定量表（FACT-G）评分的情况。比较2组患者治疗前后白细胞介素6（IL-6）、超敏C反应蛋白（hs-CRP）、肿瘤坏死因 子 α（TNF-α）以及 T 淋巴细胞亚群指标[CD3+ 、CD4+ 、CD8+ 、CD4+ /CD8+ ]的变化情况。【结果】（1）观察组总有效率为 95.08% （58/61），对照组为77.05%（47/61）。观察组疗效优于对照组，差异有统计学意义（P < 0.05）。（2）治疗后，2组患者的中医证候 积分均明显改善（P < 0.05），且观察组在改善中医证候积分方面明显优于对照组，差异有统计学意义（P < 0.05）。（3）治疗后， 2 组患者的 PFS 评分明显改善（P < 0.05），且观察组在改善 PFS 评分方面明显优于对照组，差异有统计学意义（P < 0.05）。 （4）治疗后，2组患者的血清IL-6、hs-CRP、TNF-α水平均明显改善（P < 0.05），且观察组在改善血清IL-6、hs-CRP、TNF-α 水平方面明显优于对照组，差异均有统计学意义（P < 0.05）。（5）治疗后，2组患者的CD3+ 、CD4+ 、CD8+ 、CD4+ /CD8+ 均明显改 善（P < 0.05），且观察组在改善CD3+ 、CD4+ 、CD8+ 、CD4+ /CD8+ 方面明显优于对照组，差异均有统计学意义（P < 0.05）。（6）治疗 后，2组患者的KPS评分、FACT-G评分均明显改善（P < 0.05），且观察组在改善KPS评分、FACT-G评分方面明显优于对照 组，差异有统计学意义（P < 0.05）。【结论】 调任通督电针治疗中晚期宫颈癌CRF，可有效缓解患者的疲乏症状，抑制炎症因 子的释放，调节免疫功能，改善患者的身体状况，从而提高患者的生存质量，临床疗效显著。

Objective To observe the clinical efficacy of regulating conception vessel and unblocking governor vessel electroacupuncture in the treatment of cancer-related fatigue（CRF）of middle-to-advanced stage cervical cancer， and to explore its effect on inflammatory factors. Methods A total of 122 patients with a definitive diagnosis of CRF of middle-to-advanced stage cervical cancer admitted to the wards and outpatient clinics of Cangzhou Central Hospital from August 2021 to August 2023 were selected for the study. The patients were randomly divided into the control group and the observation group according to the random number table method， with 61 cases in each group. The patients in both groups were given conventional symptomatic treatments such as gastric protection and anti-vomiting since the day of action of chemotherapy. The control group was treated with Dexamethasone Tablets，and the observation group was treated with regulating conception vessel and unblocking governor vessel electroacupuncture on the basis of the control group，the course of treatment covered 21 days. After three weeks of treatment， the clinical efficacy of the two groups was evaluated. The changes in the traditional Chinese medicine（TCM）syndrome scores，Piper􀆳s Fatigue Scale（PFS）scores，Karnofsky Performance Status （KPS）scores，and Functional Assessment of Cancer Therapy-General（FACT-G）scores of the patients in the two groups before and after treatment were observed. The changes in interleukin 6（IL-6），hypersensitive C-reactive protein（hs-CRP），tumor necrosis factor α（TNF-α），and T-lymphocyte subsets indicators [CD3+ ，CD4+ ，CD8+， CD4+/CD8+] were compared between the patients in the two groups before and after treatment. Results（1）The total effective rate was 95.08%（58/61）in the observation group and 77.05%（47/61）in the control group. The efficacy of the observation group was superior to that of the control group， the difference being statistically significant （P < 0.05）.（2）After treatment，the TCM syndrome scores of patients in the two groups were significantly improved （P < 0.05），and the improvement in the observation group was significantly superior to that in the control group， the difference being statistically significant（P < 0.05）.（3）After treatment，the PFS scores of patients in the two groups were improved significantly（P < 0.05），and the improvement in the observation group was significantly superior to that in the control group，the difference being statistically significant（P < 0.05）.（4）After treatment， the serum IL-6，hs-CRP，and TNF-α levels of patients in the two groups were significantly improved（P < 0.05）， and the improvement in the observation group was significantly superior to that in the control group，the difference being statistically significant（P < 0.05）.（5）After treatment，the CD3+，CD4+，CD8+，CD4+/CD8+ of patients in the two groups were significantly improved（P < 0.05）， and the improvement in the observation group was significantly superior to that in the control group，the difference being statistically significant（P < 0.05）.（6）After treatment，the KPS scores and FACT-G scores of patients in the two groups were significantly improved（P < 0.05）， and the improvement in the observation group was significantly superior to that in the control group，the difference being statistically significant（P < 0.05）. Conclusion Regulating conception vessel and unblocking governor vessel electroacupuncture in the treatment of CRF of middle-to-advanced stage cervical cancer can effectively alleviate the fatigue of patients，inhibit the release of inflammatory factors，regulate the immune function，and improve the physical condition of patients，so as to improve the quality of life of patients.

R246.9

河北省中医药管理局科研计划资助项目（编号：2022271）