【目的】 探索中脘穴的组方规律和临床应用规律，为临床治疗选穴提供参考。【方法】 搜集中国知网、维普数据网、万 方数据库中近20年文献中含有中脘穴的腧穴处方，进行严格筛选，将符合条件的腧穴处方中所有腧穴整理录入Excel表中， 运用 IBM SPSS Statistics 25.0软件、IBM SPSS Modeler 18.0软件、Cytoscape 3.10.1软件、apriori算法分析中脘穴的取穴组方规 律和临床应用规律。【结果】 经筛选，共纳入781篇文献，830个腧穴处方，累计183个腧穴，135个疾病。中脘常用配伍取穴 前5位分别是足三里、内关、天枢、关元和气海。穴位配伍中使用频次最高的腧穴为足三里（支持度61.205%），含中脘穴的 取穴处方中使用频次较多的经脉是足阳明胃经、足太阳膀胱经和任脉，配伍腧穴以下合穴、合穴、募穴、络穴、输穴、原 穴等特定穴为主，治疗的优势疾病有顽固性呃逆、胃炎、功能性消化不良等。其中，消化系统所属疾病最多，其次是内分 泌系统疾病。【结论】 通过数据挖掘分析发现，中脘穴的配伍腧穴有一定的规律可循，在治疗方面对某些优势疾病有较好的 疗效，可为临床治疗和科研提供参考和借鉴。

Objective To observe the rules of medication and clinical application of Zhongwan（RN12）point， thus to provide reference for the selection of acupoints in clinical treatment. Methods Collect the Zhongwan pointinvolved prescriptions in the literature of the last 20 years in China National Knowledge Infrastructure（CNKI）， China Science and Technology Journal Database（VIP）and Wanfang Data Knowledge Service Platform，conduct strict screening，organize and record all the acupoints involved in the prescriptions，of which met the acupoint selection criteria， into Excel tables， then use IBM SPSS Statistics 25.0 software， IBM SPSS Modeler 18.0 software，Cytoscape 3.10.1 software，apriori algorithm to analyze the rules of medication and clinical application of Zhongwan point. Results After screening，a total of 781 articles with 830 acupoint-involved prescriptions were included，involves 183 acupoints and 135 diseases. With the leading five acupoints which ranked in decending order of selection was as follows：Zusanli（ST36），Neiguan（PC6），Tianshu（ST25），Guanyuan（BL26）and Qihai（RN6）. The distribution of acupoints with the highest frequency of use in combination acupoints was Zusanli （61.205% support），and the meridians with a higher frequency of use in Zhongwan point-involved prescriptions were the foot-yangming stomach meridian，the foot-taiyang bladder meridian，and the conception vessel（CV）， with the combination acupoints dominated by the specific acupoints of Xiahe points，He points，front-Mu points， collateral points，Shu Points，and original points，the advantageous diseases were characterized by intractable hiccups，gastritis，functional dyspepsia and so on. Among them，the diseases pertain to the digestive system were the most involved，followed by endocrine system diseases. Conclusion The data mining analysis yielded that there are certain rules to be followed in the acupoints combination of Zhongwan point，and it exerts some efficacy in the treatment of certain advantageous diseases， which can provide references for clinical treatment and scientific research.

R246.9

国家自然科学基金资助项目（编号：82205290）；山东中医药大学科研创新基金课题资助项目（编号：2018-220315）