“浊菀清窍”是蔡业峰教授基于多年临证经验而提出的脑病病机学说。该文分析了“浊菀清窍”的概念内涵及其演变；通过总结历代医家的经验和学说阐释“浊菀清窍”病机假说的理论内涵，即“浊菀本阴，其性从化”的病因特性，“病在清窍，影响神机”的致病机制及“起病隐匿，胶着缠绵”的致病特点，并由此提出“化浊菀，开清窍”的核心治则；结合中医药干预脑病的现代实验研究和临床研究，阐明其临床意义及应用前景。“浊菀清窍”脑病病机学说的提出可促进中医脑病病机理论的创新，为脑病的现代临床诊疗提供方向。

The hypothesis of “turbidity stagnating in upper orifices” for pathogenesis of encephalopathy is proposed by Professor CAI Ye-Feng based on his years of clinical experience. This paper analyzed the conceptual connotation of “turbidity stagnating in upper orifices” and its evolution，and clarified the theoretical connotation of the hypothesis of “turbidity stagnating in upper orifices” by summarizing the experiences and doctrines of ancient medical practitioners. It is revealed that turbidity stagnation originally belongs to yin，and is apt to transform with other pathogens in etiological nature；turbidity stagnation usually affects the upper orifices in the pathogenic mechanism，and has the pathogenic characteristics of onset after an incubation period and being complicated and lingering. Therefore，the therapeutic principle of “eliminating turbidity stagnation，unblocking upper orifices” for encephalopathy has been put forward. The clinical implication of hypothesis of “turbidity stagnating in upper orifices” was illustrated in this paper by reviewing the modern experimental study and clinical trials of intervention of encephalopathy with traditional Chinese medicine （TCM） ，and its clinical application was also prospected. The hypothesis of “turbidity stagnating in upper orifices” for pathogenesis of encephalopathy is expected to promote the theoretical innovation for the TCM pathogenesis of encephalopathy，and will provide a direction for the modern clinical diagnosis and treatment of encephalopathy.

R277.743

广东省中医药管理局广东省名中医传承工作室建设项目 （粤中医办函[2023]108号）；广东省中医院中医学术流派传承工作室建设项目 （编号：E43604）