介绍陈贵珍教授治疗早发性卵巢功能不全的临证经验。陈贵珍认为，早发性卵巢功能不全病因病机是先天肾精不足，后天脾胃乏源，肝失疏泄，终致天癸乏源，冲任失调。故治疗上强调“补肾益癸，健脾疏肝，调理冲任”为原则。临证选穴重视俞募配穴；针法讲究飞针定志、傍针固气，巧用埋线，三位一体，线药并用。辨证治疗早发性卵巢功能不全，最终 达到冲任调和的目的。

This article introduces the clinical experience of professor CHEN Gui-Zhen in treating premature ovarian insufficiency （POI） . According to professor CHEN Gui-Zhen，the etiology and pathogenesis of POI is congenital insufficiency of kidney essence，failure of acquired source of production and transformation of spleen and stomach，and failure of liver to maintain free movement of qi，which leads to failure of production and transformation source of sex-stimulating essence，disharmony of Chong and Conception Channels. Therefore，professor CHEN Gui-Zhen emphasizes the principle of “tonifying kidney and replenishing sex-stimulating essence，invigorating the spleen and dispersing the stagnated liver-energy，regulating Chong and Conception Channels” during treatment. As for the clinical acupoint selection，the combination of back-shu and front-mu points method is valued，as for the acupuncture technique，professor CHEN uses the flying needle therapy to calm mind，and straight-side acupuncture to strenghthening qi，and acupoint catgut embedding therapy skillfully，she trinity the above treatment methods，and combined use of acupoint catgut embedding and medicine. The treatment of POI is based on syndrome differentiation，and the purpose of harmony of Chong and Conception Channels is finally achieved.

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国家自然科学基金资助项目 （编号：81473755，81574064）；广东省自然科学基金面上资助项目 （编号：2024A1515011874） ；深圳市科技计划资助项目 （编号：JCY20210324124613037）；深圳市宝安中医药发展基金资助项目 （编号：2022KJCX-ZJZL-10）；深圳市宝安区中医药协会项目 （编号：2023ZYYLCZX-20）；广东省研究生教育创新资助项目 （编号：2022XSLT014）