【目的】观察针刺治疗强直性脊柱炎睡眠障碍患者的临床疗效。 【方法】将60例强直性脊柱炎睡眠障碍患者随机分为观察组和对照组，每组各30例。对照组给予柳氮磺吡啶肠溶片和塞来昔布胶囊口服，观察组在对照组治疗的基础上给予针刺治疗，连续治疗4周。治疗1个月后，评价2组临床疗效，观察2组患者治疗前后匹兹堡睡眠质量指数 （PSQI） 、医院焦虑抑郁量表 （HADS） 评分的变化情况，以及巴氏强直性脊柱炎疾病活动指数 （BASDAI） 、巴氏强直性脊柱炎功能指数 （BASFI） 的情况。比较2组患者治疗前后C-反应蛋白 （CRP） 含量的变化情况。并评价2组的安全性及不良反应的发生情况。 【结果】（1） 治疗后，2组患者的PSQI、BASDAI评分明显改善 （P＜0.05） ，且观察组在改善PSQI、BASDAI评分方面明显优于对照组，差异有统计学意义 （P＜0.05） 。 （2） 治疗后，2组患者的HADS （A） 与HADS （D） 评分明显改善 （P＜0.05） ，观察组在改善HADS （A） 与HADS （D） 评分方面稍优于对照组，但差异无统计学意义 （P＞0.05） 。 （3） 治疗后，2组患者的BASFI评分稍有改善，但差异无统计学意义 （P＞0.05） 。 （4） 治疗后，2组患者的CRP含量明显改善 （P＜0.05） ，且观察组在改善CRP含量方面明显优于对照组，差异有统计学意义 （P＜0.05） 。 （5） 观察组总有效率为83.33% （25/30） ，对照组为60.00% （18/30） 。观察组疗效优于对照组，差异有统计学意义 （P＜0.05） 。 （6） 观察组和对照组的不良反应发生率比较，差异无统计学意义 （P＞0.05） 。 【结论】针刺治疗强直性脊柱炎睡眠障碍，可有效改善患者的睡眠质量、疾病活动度和炎症指标，改善患者的临床症状，且安全可行，无明显不良反应，疗效显著。

Objective To observe the clinical efficacy of acupuncture in the treating patients with sleep disorder in ankylosing spondylitis. Methods A total of 60 patients with sleep disorder in ankylosing spondylitis were randomly divided into observation group and control group，30 cases in each group. The control group was given oral administration of Liuzosulfapyridine Enteric-coated Tablets and Celecoxib Capsules，and the observation group was given acupuncture for treatment on the basis of the control group for four consecutive weeks. After one month of treatment，the clinical efficacy of the two groups was evaluated，and the changes in the Pittsburgh Sleep Quality Index （PSQI） and Hospital Anxiety and Depression Scale （HADS） scores， as well as the Bath Ankylosing Spondylitis Disease Activity Index （BASDAI） and Bath Ankylosing Spondylitis Functional Index （BASFI） were observed in the patients of the two groups before and after treatment. The changes in C-reactive protein （CRP） levels between the two groups of patients before and after treatment were compared. And the safety and the occurrence of adverse reactions in the two groups were evaluated. Results （1） After treatment，the PSQI and BASDAI scores of patients in the two groups were improved significantly （P＜0.05） ，and the improvement in the observation group was significantly superior to that in the control group， and the difference was statistically significant （P＜0.05） . （2） After treatment，the HADS（A） and HADS（D） scores of patients in the two groups were improved significantly （P＜0.05） ，and the improvement in the observation group was slightly superior to that in the control group，but the difference was not statistically significant （P＞0.05） . （3） After treatment，the BASFI scores of patients in the two groups were slightly improved，but the difference was not statistically significant（P＞0.05） . （4）After treatment，the CRP levels of patients in the two groups were improved significantly（P＜0.05） ，and the improvement in the observation group was significantly superior to that in the control group，and the difference was statistically significant （P＜0.05） . （5） The total effective rate was 83.33% （25/30） in the observation group and 60.00% （18/30） in the control group. The efficacy of the observation group was superior to that of the control group， and the difference was statistically significant （P＜0.05） . （6） Comparison of the incidence of adverse reactions between the observation group and the control group， the difference was not statistically significant（P＞0.05） . Conclusion Acupuncture in treating sleep disorders in ankylosing spondylitis can effectively improve patients’ sleep quality，disease activity and inflammation indexes，and improve patients’ clinical symptoms，and it is safe and feasible，without obvious adverse reactions，and the efficacy is remarkable.

R246.9

广东省中医院针药相须流派传承工作室建设资助项目 （编号：中医二院 [2013]233号-12）