【目的】探讨平调颗粒联合西医常规治疗对肝阳上亢型高血压合并睡眠障碍患者血压变异性和睡眠质量的影响。 【方法】采用回顾性研究方法，选取2020年12月至2023年12月期间在广东省第二中医院接受治疗的152例肝阳上亢型高血压合并睡眠障碍患者为研究对象。根据治疗方案的不同，将患者分为对照组和观察组，每组各76例。对照组单纯给予缬沙坦降压治疗，观察组在对照组的基础上给予平调颗粒治疗，疗程为4周。观察2组患者治疗前后的动态血压、血压变异性 （BPV） 、阿森斯失眠量表 （AIS） 评分的变化情况，并比较2组患者治疗期间的不良反应发生情况。 【结果】（1） 动态血压方面：治疗后，2组患者的24 h收缩压 （24hASBP） 、24 h舒张压 （24hADBP） 、血压晨峰 （MBPS） 均较治疗前明显下降 （P＜0.01） ，且观察组的下降幅度均明显优于对照组 （P＜0.01） 。 （2） BPV方面：治疗后，2组患者的24 h收缩压标准差 （24hSSD） 、24 h舒张压标准差（24hDSD） 、白昼收缩压标准差 （dSSD） 、白昼舒张压标准差 （dDSD） 、夜间收缩压标准差 （nSSD） 、夜间舒张压标准差 （nDSD）等各项BPV指标均较治疗前下降 （P＜0.05或P＜0.01） ，且观察组的下降幅度均明显优于对照组 （P＜0.05或P＜0.01） 。 （3） 睡眠状况方面：治疗后，2组患者的睡眠质量均显著提升，AIS评分及其分级情况均较治疗前明显改善 （P＜0.01） ，且观察组的改善幅度均明显优于对照组 （P＜0.01） 。 （4） 不良反应方面：治疗期间，2组患者均未出现严重不良反应，观察组的不良反应发生率为3.95% （3/76） ，对照组为11.84% （9/76） ，组间比较，差异无统计学意义 （P＞0.05） 。 【结论】在常规西药治疗基础上联合平调颗粒可显著改善肝阳上亢型高血压合并睡眠障碍患者的血压变异性，降低血压水平及清晨血压波动，提高睡眠质量，且具有较高的安全性。

Objective To investigate the effects of Pingtiao Granules combined with conventional western medical treatment on blood pressure variability （BPV） and sleep quality in patients with hypertension complicated by sleep disorders of liver yang hyperactivity type. Methods A retrospective study was carried out in 152 patients with hypertension complicated by sleep disorders of liver yang hyperactivity type who were treated in Guangdong Second Traditional Chinese Medicine Hospital from December 2020 to December 2023. According to the treatment regimen，the patients were divided into the control group and the observation group，with 76 cases in each group. The control group was given Valsartan alone for antihypertensive therapy，and the observation group was treated with Pingtiao Granules on the basis of treatment for the control group. The course of treatment for the two groups covered four weeks. Before and after treatment，the changes of ambulatory blood pressure，BPV indicators，Athens Insomnia Scale （AIS） scores of the two groups were observed. Moreover，the incidence of adverse reactions in the two groups during treatment was compared. Results （1） After treatment，the ambulatory blood pressure indicators such as 24-hour ambulatory systolic blood pressure （24hASBP），24-hour ambulatory diastolic blood pressure （24hADBP） ，and morning blood pressure surge （MBPS） in the two groups were decreased significantly when compared with those before treatment （P＜0.01） ，and the decrease in the observation group was significantly superior to that in the control group （P＜0.01） . （2） After treatment，the BPV indicators such as 24-hour systolic standard deviation （24hSSD）， 24-hour diastolic standard deviation （24hDSD）， daytime systolic standard deviation （dSSD） ，daytime diastolic standard deviation （dDSD） ，nighttime systolic standard deviation （nSSD） ，and nighttime diastolic standard deviation （nDSD） in the two groups were decreased when compared with those before treatment （P＜0.05 or P＜0.01） ，and the decrease of all of the BPV indicators in the observation group was significantly superior to that in the control group （P＜0.05 or P＜0.01） . （3） The sleep quality of the patients in the two groups was significantly improved， and the AIS score and its grading were significantly improved when compared with those before treatment （P＜0.01） ，and the improvement in the observation group was significantly superior to that in the control group （P＜0.01） . （4） During the treatment，no serious adverse reactions occurred in the two groups，and the incidence of adverse reactions in the observation group was 3.95% （3/76） and that in the control group was 11.84%（9/76），showing no statistically significant difference （P＞0.05） . Conclusion The application of Pingtiao Granules on the basis of western medicine is effective on improving BPV in patients with hypertension complicated by sleep disorders of liver yang hyperactivity type，and can also reduce blood pressure level and morning blood pressure fluctuation and improve the quality of sleep of the patients，with high safety.

R259.441

广东省中医药局科研项目 （编号：20221028）；广东省中医特色重点医院建设工程项目 （编号：粤财社[2023]139号）；2023年度广东省第二中医院科研创新基金资助项目 （编号：SEZYY2023B18）