【目的】基于数据挖掘方法探讨痞满病的中医证型分布情况及中药治疗痞满病的用药规律。 【方法】运用中医传承计算平台V3.5对2023年1月至2024年1月就诊于深圳市中医院脾胃病科门诊的痞满病患者的病例资料进行统计分析，并通过该软件自带的高级数据挖掘算法，以探讨痞满病的中医证型分布情况以及中药治疗痞满病的用药规律。 【结果】共纳入符合标准的病例387例，其主要证型为脾虚气滞证、脾胃虚弱证、脾虚湿蕴证，分别占21.45% （83/387） 、14.99% （58/387） 、14.99%（58/387） 。中药治疗痞满病的高频药物为姜厚朴、茯苓、炙甘草、党参片、陈皮；药物性味以甘温药最多，归经多分布于脾胃经、肺经。基于Apriori关联规则算法，居前3位的核心药物组合为“姜厚朴-茯苓”“茯苓-炙甘草”和“姜厚朴-炙甘草”；通过聚类分析共提取出4首中药治疗痞满病的新方组合。 【结论】痞满病的主要病机为脾胃气虚，兼杂水湿、气滞等，本虚标实，虚滞相兼；治疗多以健脾益气为法，随证加减，辅以行气、化痰、燥湿等，兼顾虚实。

Objective To investigate the distribution of traditional Chinese medicine （TCM） syndrome types in the patients with stuffiness-fullness disease （disorders with the sensation of stuffiness and fullness in the chest or epigastrium but without pain） and the medication rules of Chinese herbal medicines in treating stuffiness-fullness disease by the data mining method，so as to provide a reference basis for the TCM diagnosis and treatment of stuffiness-fullness disease. Methods Traditional Chinese Medicine Inheritance Computing System（TCMICS）V3.5 was used for the statistical analysis of the medical case data of outpatients with stuffiness-fullness disease from the Department of Spleen and Stomach Diseases of Shenzhen Traditional Chinese Medicine Hospital from January 2023 to January 2024. The advanced data mining algorithms of TCMICS V3.5 were used to explore the distribution of TCM syndrome types of stuffiness-fullness disease and the medication rules of Chinese herbal medicines in the treatment of stuffiness-fullness disease. Results （1） A total of 387 cases that met the criteria were included for analysis，and the patients were usually differentiated as the TCM syndrome types of spleen deficiency and qi stagnation syndrome，spleen and stomach weakness syndrome，spleen deficiency and dampness accumulation syndrome，which accounted for 21.45% （83/387） ，14.99% （58/387） ，and 14.99% （58/387） ，respectively. The high-frequency Chinese herbal medicines for the treatment of stuffiness-fullness disease were ginger-prepared Cortex Magnoliae Officinalis，Poria，Glycyrrhizae Radix et Rhizoma Praeparata cum Melle，sliced Codonopsis Radix，and Citri Reticulatae Pericarpium. Most of the Chinese herbal medicines for stuffiness-fullness disease were warm and sweet in the properties and flavors，and had the meridian tropism of the spleen meridian，stomach meridian and the lung meridian. The Apriori association rule algorithm achieved the top three core drug combinations，and they were ginger-prepared Cortex Magnoliae Officinalis-Poria，Poria-Glycyrrhizae Radix et Rhizoma Praeparata cum Melle，and ginger-prepared Cortex Magnoliae Officinalis-Glycyrrhizae Radix et Rhizoma Praeparata cum Melle. A total of four new prescriptions of Chinese herbal medicines for stuffiness-fullness disease were obtained after cluster analysis. Conclusion It is revealed that the main pathogenesis of stuffiness-fullness disease is due to qi deficiency of spleen and stomach complicated with water-dampness and qi stagnation，and the disease is characterized by deficiency in the origin and excess in the superficiality，usually with the mixture of deficiency and stagnation. For the treatment of stuffiness-fullness disease，therapies of invigorating spleen and replenishing qi are frequently adopted，and herbs for activating qi，resolving phlegm，and drying dampness can be flexibly chosen according to the specific syndromes，thus to treat both of the deficiency syndrome and excess syndrome.

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国家自然科学基金青年科学基金项目 （编号：82305107）