百合地黄汤是《金匮要略》中的经典方剂，具有养阴清热、补益心肺的功效。百合地黄汤及其类方在抑郁症、失眠、妇女更年期综合征等精神类疾病中应用较广泛。该文通过查阅近年来有关百合地黄汤及其类方百合知母汤、百合鸡子汤在治疗抑郁症方面的相关文献，对百合地黄汤及其类方治疗抑郁症的临床应用及其可能的药理机制进行综述。分析显示，百 合地黄汤及其类方主要适用于阴虚内热证型患者，可通过上调单胺类神经递质水平和脑源性神经营养因子的表达、抑制炎症反应、保护神经元和调节能量代谢等途径，从而达到改善抑郁状态的效果。通过对百合地黄汤及其类方抗抑郁的临床应用和可能作用机制的分析，可为抑郁症的临床治疗和基础研究提供参考。

Baihe Dihuang Decoction is a classic formula recorded in Jin Gui Yao Lve （Synopsis of the Golden Chamber），which has the actions of nourishing yin and clearing heat，tonifying heart and lung. Baihe Dihuang Decoction and its associated formulas are widely used for the treatment of depression， insomnia， women’ s menopausal syndrome and other psychiatric disorders. This article retrieved the relevant literature about Baihe Dihuang Decoction and its associated formulas such as Baihe Zhimu Decoction and Baihe Jizi Decoction for the treatment of depression in recent years，and analyzed the clinical application and the possible pharmacological mechanisms of Baihe Dihuang Decoction and its associated formulas for the treatment of depression. The analysis showed that Baihe Dihuang Decoction and its associated formulas were indicated for the patients with internal heat due to yin deficiency syndrome，and their antidepressive mechanism is related to up-regulating the levels of monoamine neurotransmitters and the expression of brain-derived neurotrophic factors，inhibiting inflammatory responses，protecting neurons and regulating energy metabolism. The analysis results for the clinical application and possible therapeutic mechanism of Baihe Dihuang Decoction and its associated formulas in counteracting depression will provide reference for the clinical treatment and basic research of depression.

R222.16；R256.29

广东省中医药局面上项目 （编号：20221202）