【目的】利用数据挖掘技术深层次探究国医大师禤国维教授治疗白癜风的药物配伍原则，并通过网络药理学分析其核心药对的潜在作用机制。 【方法】整理禤国维教授治疗白癜风的原始医案，再用中医传承辅助平台软件，采用关联规则方法，确定处方中药物频次、药物之间的关联规则和核心组合等，根据数据挖掘结果得出禤国维教授治疗白癜风的核心药对，再利用网络药理学方法对核心药对的作用机理进行分析讨论。 【结果】收录处方243首，其中高频次药物为甘草、蒺藜、旱莲草、菟丝子、玄参、白芷等，核心药对为蒺藜-旱莲草。蒺藜-旱莲草治疗白癜风的主要成分为槲皮素、山奈酚等，活性成分与疾病交集靶点47个，其中TP53、TNF、IL-1β、CASP3、VEGFA、PTGS2、IL10、IL2、IFNG、IL4 可能是蒺藜-旱莲草治疗白癜风的核心靶点。蒺藜-旱莲草药对对抗疾病的主要通路有PI3K-Akt信号通路、NF-κB信号通路、JAK-STAT信号通路、MAPK信号通路等。 【结论】 禤国维教授治疗白癜风的核心药对是蒺藜-旱莲草，涉及的靶点有TP53、TNF、IL-1β、CASP3、VEGFA、PTGS2、IL10、IL2、IFNG、IL4 等，可能是通过PI3K-Akt信号通路、NF-κB信号通路、JAK-STAT信号通路、MAPK信号通路等起作用。

Objective To deeply explore the principles of drug combinations in the treatment of vitiligo by traditional Chinese medicine master XUAN Guo-Wei by data mining technology，and to analyze the potential mechanism of action of the core drug pairs by network pharmacology. Methods The original case records of Professor XUAN Guo-Wei in treating vitiligo were compiled，and then TCM inheritance Computing Platform was used to analyze the frequency of drugs in the prescriptions，the association rules between drugs，and the core combinations of drugs by the association rule method，and the core drug pairs of Professor XUAN Guo-Wei’ s treatment of vitiligo were obtained based on the results of the data mining，additionally，the mechanism of the core pairs of drugs was analyzed by using the method of network pharmacology. Results A total of 243 prescriptions were collected，among which the high-frequency drugs were Glycyrrhizae Radix et Rhizoma， Tribuli Fructus，Ecliptae Herba，Cuscutae Semen，Scrophulariae Radix，Angelicae Dahuricae Radix，etc.，and the core pair was Tribuli Fructus-Ecliptae Herba. The main components of Tribuli Fructus-Ecliptae Herba for the treatment of vitiligo were quercetin，kaempferol，etc.，there were 47 targets for the intersection of the active ingredients with the disease，among which TP53，TNF，IL-1β，CASP3，VEGFA，PTGS2，IL10，IL2，IFNG，and IL4 may be the core targets for the treatment of vitiligo by Tribuli Fructus-Ecliptae Herba. The main pathways of Tribuli Fructus-Ecliptae Herba drug pairs against the disease were PI3K-Akt signaling pathway， NF- κB signaling pathway，JAK-STAT signaling pathway and MAPK signaling pathway. Conclusion The core drug pair of Professor XUAN Guo-Wei in the treatment of vitiligo is Tribuli Fructus-Ecliptae Herba，which involves targets such as TP53，TNF，IL-1β，CASP3，VEGFA，PTGS2，IL10，IL2，IFNG，IL4，etc.，Tribuli Fructus-Ecliptae Herba drug pair maybe exert an effect in the treatment of vitiligo through PI3K-Akt signaling pathway，NF-κB signaling pathway，JAK-STAT signaling pathway and MAPK signaling pathway.

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国家重点研发计划项目 （编号：2018YFC1704100）