【目的】观察针刺联合俞募穴埋线和神阙穴外敷治疗卵巢早衰的临床疗效。 【方法】将62例卵巢早衰 （POF） 患者随机分为观察组和对照组，每组各31例，观察组给予益肾固冲调神针法针刺联合俞募穴埋线和神阙穴外敷治疗，对照组给予激素替代疗法治疗。连续治疗3个月。治疗3个月后，评价2组临床疗效，观察2组患者治疗前后中医证候积分的变化情况，以及卵巢体积、窦卵泡数、窦卵泡直径的情况。比较2组患者治疗前后血清卵泡刺激素 （FSH） 、促黄体生成素 （LH） 、雌二醇（E2） 水平的变化情况。 【结果】（1） 观察组总有效率为93.55% （29/31） ，对照组为80.64% （25/31） 。观察组疗效明显优于对照组，差异有统计学意义 （P＜0.05） 。 （2） 治疗后，2组患者血清FSH、LH、E2水平均明显改善 （P＜0.05） ，且观察组在改善血清FSH、LH、E2水平方面明显优于对照组，差异有统计学意义 （P＜0.05） 。 （3） 治疗后，2组患者卵巢体积、窦卵泡数、窦卵泡直径均明显改善 （P＜0.05） ，且观察组在改善卵巢体积、窦卵泡数、窦卵泡直径方面明显优于对照组，差异有统计学意义（P＜0.05） 。 【结论】益肾固冲调神针法针刺联合俞募穴埋线和神阙穴外敷治疗卵巢早衰，能明显改善患者的临床症状，有助于卵巢功能的恢复，能明显改善患者的性激素水平，临床疗效确切。

Objective To observe the clinical efficacy of acupuncture combined with acupoint catgut embedding therapy on back-shu and front-mu points and external application on shenque （RN8） point for premature ovarian failure （POF） . Methods A total of 62 patients with POF were randomly divided into the observation group and the control group，with 31 patients in each group. The observation group was treated with acupuncture combined with acupoint catgut embedding therapy on back-shu and front-mu points and external application on shenque point，and the control group was treated with hormone replacement therapy. After three months of treatment，the clinical efficacy of the two groups was evaluated，and the changes in the traditional Chinese medicine （TCM） syndrome scores，as well as the ovarian volume，number of antral follicle，and antral follicle diameter of the patients in the two groups before and after treatment were observed. The changes of serum follicle stimulating hormone （FSH），luteinizing hormone （LH） and estradiol （E2） levels before and after treatment were compared between the two groups. Results （1） The total effective rate was 93.55% （29/31） in the observation group and 80.64% （25/31） in the control group. The efficacy of the observation group was significantly superior to that of the control group，and the difference was statistically significant （P＜0.05） . （2） After treatment，the serum FSH，LH and E2 levels of patients in the two groups were significantly improved （P＜0.05） ，and the improvement in the observation group was significantly superior to that in the control group，with statistically significant differences （P＜0.05） . （3） After treatment，ovarian volume，number of antral follicle，and antral follicle diameter were significantly improved in the two groups （P＜0.05） ，and the improvement in the observation group was significantly superior to that in the control group，and the difference was statistically significant （P＜0.05） . Conclusion The treatment of POF with acupuncture combined with acupoint catgut embedding therapy on back-shu and front-mu points and external application on shenque point can significantly improve the clinical symptoms of the patients，conducive to the recovery of ovarian function，and significantly improve the sex hormone levels of the patients，with precise clinical efficacy.

R246.9

广东省中医药局科研项目 （编号：20231267）