【目的】通过研究慢性阻塞性肺疾病（简称慢阻肺）患者的出生日期、急性加重日期的五运六气特点，探讨运气禀赋与慢阻肺发病的相关性，为其临床防治提供中医运气学的辨治思路。【方法】运用流行病学横断面研究方法，结合中医五运六气时间划分，对3411例慢阻肺患者进行回顾性分析研究。【结果】（1）出生日期运气分布：主气以阳明燥金最多；客主加临以太阴湿土-阳明燥金最多；五运三纪以火运太过残差最大；综合运气以太徵-少阳相火-厥阴风木最多。上述出生日期的运气分布比较，差异均有统计学意义（P＜0.05或P＜0.01）。（2）急性加重日期运气分布：岁运以太徵、少宫居多；司天-在泉以太阳寒水-太阴湿土残差最大；客气以阳明燥金最多；客主加临以阳明燥金-少阴君火最多；五运三纪以木运平气残差最大；综合运气以太徵-太阳寒水-太阴湿土最多。上述急性加重日期的运气分布比较，差异均有统计学意义（P＜0.05或P＜0.01）。【结论】慢阻肺病例运气禀赋与发病趋势存在一定的五运六气关联，通过分析慢阻肺患者出生日期和急性加重日期的五运六 气特点，有利于较早发现易患人群和急性加重时间，及早进行干预、未病先防。

Objective To explore the correlation between the circuit qi endowment and the prevalence of chronic obstructive pulmonary disease（COPD）by studying the characteristics of five circuits and six qi at birth date and on the date of acute exacerbation of patients with COPD，so as to provide the traditional Chinese medicine（TCM）circuit-qi thoughts for clinical prevention and treatment of diseases. Methods An epidemiological cross-sectional study was carried out in 3 411 patients with COPD. The correlation of the prevalence of COPD with the circuit qi at birth date and on the date of acute exacerbation was retrospectively analyzed after time conversion according to the rules of five circuits and six qi in TCM. Results （1）The analysis of circuit qi at birth date showed that the dominant qi of COPD patients at birth date was predominated by yangming dry-gold，the joining of guest qi with dominant qi was predominated by taiyin damp-earth and yangming dry-gold，the three patterns of five circuits（the excess，deficiency and balanced state of yearly evolutive phase）were characterized by excess fire circuit with the maximum residual，and the comprehensive circuit qi was predominated by taizheng（excess fire circuit），shaoyang ministerial fire and jueyin wind-wood. There were statistically significant differences in the distribution of above circuit qi at birth date（P＜0.05 or P＜0.01）. （2）The analysis circuit qi on the date of acute exacerbation showed that the suiyun（yearly evolutive phase）was predominated by taizheng（excess fire circuit）and shaogong（deficiency earth circuit），the sitian-zaiquan semiannual circuit qi was characterized by taiyang cold-water and taiyin damp-earth with the maximum residual；the guest qi was predominated by yangming dry-gold，the joining of guest qi with dominant qi was predominated by yangming dry-gold and shaoyin monarch fire，the three patterns of five circuits （the excess，deficiency and balanced state of yearly evolutive phase）were characterized by the balanced wood circuit with the maximum residual，and the comprehensive circuit qi was predominated by taizheng（excess fire circuit），taiyang cold-water，and taiyin damp-earth. There were statistically significant differences in the distribution of above circuit qi on the date of acute exacerbation of COPD（P＜0.05 or P＜0.01）. Conclusion There is a certain correlation between the circuit qi endowment and the prevalence of COPD. The analysis of the five-circuit and six-qi characteristics of COPD patients at birth date and on the date of acute exacerbation will be helpful for the early identification of susceptible population and acute exacerbations，so as to perform early intervention and prevention before illness.

R259.63

国家自然科学基金项目 （编号：82074343）；中华中医药学会青年求实项目 （编号：2022-QNQSDEP-04）；广东省中医院中医药科学技术研究专项 （编号：YN2022MS13）；广东省中医院顾植山学术经验传承工作室项目 （编号：广中医文[2014]089号）