基于类风湿关节炎患者“风湿瘀阻，筋伤骨损”的病机特点，提出“祛风除湿，通利血脉，畅通经络，健脾补肾， 强筋壮骨”的治法，简称“祛湿通脉法”。在“祛湿通脉法”治疗原则的指导下，可根据正邪虚实，选用经验方如昆断益母 方、南续益母颗粒、三藤舒筋方以及经方如桂枝芍药知母汤、黄芪桂枝五物汤、半夏泻心汤等进行随症加减的中药治疗， 并可配合膏方、外治法、功能锻炼等，从而构建具有中医药优势的类风湿关节炎防治体系。该课题组所开展的系列临床和实验 研究结果表明，“祛湿通脉法”治疗类风湿关节炎具有增效减毒的作用，是发挥中医药优势以防治类风湿关节炎的理论创新。

The pathogenesis of rheumatoid arthritis patients exerts the features of wind-damp and stasis obstruction，sinew injury and bone damage，therefore，the therapy of dispelling wind and removing dampness，dredging blood vessels，unblocking meridians and collaterals，invigorating spleen and kidney，and strengthening muscles and bones was proposed，hereinafter referred to as Qushi Tongmai method. Under the guidance of Qushi Tongmai method，rheumatoid arthritis can be treated with Chinese medicine based on the modification of empirical formulas such as Kunduan Yimu Formula，Nanxu Yimu Granules and Santeng Shujin Formula，and classical formulas such as Guizhi Shaoyao Zhimu Decoction，Huangqi Guizhi Wuwu Decoction and Banxia Xiexin Decoction according to the deficiency and excess of healthy qi and pathogenic qi as well as the specific symptoms. Moreover，the soft exact，external treatment and functional exercise can be also included. The Chinese medicine therapy combined with the soft exact，external treatment and functional exercise constitutes a unique Chinese medicine system for the prevention and treatment of rheumatoid arthritis. The results of a series of clinical and experimental studies indicated that Qushi Tongmai method exerts efficiency-enhancing and toxin-reducing effect in the treatment of rheumatoid arthritis，and the establishment of Qushi Tongmai method is a theoretical innovation in exerting the advantages of Chinese medicine in the prevention and treatment of rheumatoid arthritis.

R259.322

国家自然科学基金资助项目 （编号：81173634，81774262，81573930，82174301）